Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Nov;269(11):2343-8.
doi: 10.1007/s00405-012-1927-5. Epub 2012 Jan 24.

Plasma RANTES and eotaxin levels are correlated with the severity of chronic rhinosinusitis

Pin-Zhir Chao  1 , Chi-Ming Chou, Chen-Ho Chen
Affiliations

Plasma RANTES and eotaxin levels are correlated with the severity of chronic rhinosinusitis

Pin-Zhir Chao et al. Eur Arch Otorhinolaryngol. 2012 Nov.

Abstract

Eosinophilia occurs in up to 75-90% of nasal polyps in Caucasians. The chemokines eotaxin and RANTES increase eosinophil recruitment, activation, and survival, and these chemokines are significantly expressed in nasal polyps. We hypothesized that eotaxin and RANTES plasma levels might be correlated with disease severity. We compared the eotaxin and RANTES plasma levels in 20 Taiwanese patients with chronic rhinosinusitis and nasal polyps and 20 Taiwanese healthy controls. Eotaxin and RANTES plasma levels were measured by ELISA and disease severity was scored by CT scans. Compared to controls, patients with nasal polyps had significantly elevated plasma levels of eotaxin and RANTES and increased peripheral blood eosinophils (p < 0.001). Eotaxin plasma levels were significantly correlated with disease severity in patients with chronic rhinosinusitis to a greater extent than were RANTES levels. RANTES and eotaxin levels were also positively correlated with the percentages of peripheral blood eosinophils. Eotaxin plasma levels are significantly correlated with disease severity in Taiwanese patients with nasal polyposis to a greater degree than are RANTES levels. Additional studies are needed to assess whether eotaxin plasma levels can be used to monitor disease progression and attenuation.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Ann Otol Rhinol Laryngol. 1998 May;107(5 Pt 1):416-20 - PubMed
    1. Rhinology. 2007 Sep;45(3):235-41 - PubMed
    1. Curr Opin Otolaryngol Head Neck Surg. 2007 Feb;15(1):10-7 - PubMed
    1. Braz J Otorhinolaryngol. 2008 Mar-Apr;74(2):207-12 - PubMed
    1. Clin Exp Allergy. 2004 May;34(5):804-11 - PubMed

Publication types

MeSH terms

LinkOut - more resources