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Review
. 2011;13(6):229.
doi: 10.1186/bcr2905. Epub 2011 Nov 30.

β1-integrins signaling and mammary tumor progression in transgenic mouse models: implications for human breast cancer

Hicham Lahlou  1 , William J Muller
Affiliations
Review

β1-integrins signaling and mammary tumor progression in transgenic mouse models: implications for human breast cancer

Hicham Lahlou et al. Breast Cancer Res. 2011.

Abstract

Consistent with their essential role in cell adhesion to the extracellular matrix, integrins and their associated signaling pathways have been shown to be involved in cell proliferation, migration, invasion and survival, processes required in both tumorigenesis and metastasis. β1-integrins represent the predominantly expressed integrins in mammary epithelial cells and have been proven crucial for mammary gland development and differentiation. Here we provide an overview of the studies that have used transgenic mouse models of mammary tumorigenesis to establish β1-integrin as a critical mediator of breast cancer progression and thereby as a potential therapeutic target for the development of new anticancer strategies.

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Figures

Figure 1
Figure 1
β1-integrins constitute the largest subgroup of integrins. β1-integrin subunits can associate with 12 different α-subunits. All β1-integrins bind to extracellular matrix molecules. Shaded circles represent the α-subunits expressed in the mammary gland.
Figure 2
Figure 2
Schematic representation of the different integrin heterodimers expressed in mammary epithelial cells. In the mammary ducts, most integrins are concentrated at sites of contact between the mammary basement membrane and myoepithelial cells. However, luminal epithelial cells also express the α2β1, α3β1, α6β1 and α6β4 heterodimers at cell-cell junctions.
See this image and copyright information in PMC

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