Olive leaf extract modulates permethrin induced genetic and oxidative damage in rats
- PMID: 22262123
- PMCID: PMC3397112
- DOI: 10.1007/s10616-011-9424-z
Olive leaf extract modulates permethrin induced genetic and oxidative damage in rats
Abstract
Permethrin is a common synthetic chemical, widely used as an insecticide in agriculture and other domestic applications. The previous reports indicated that permethrin is a highly toxic synthetic pyrethroid pesticide to human and environmental health. Therefore, the present experiment was undertaken to determine the effectiveness of olive leaf extract in modulating the permethrin induced genotoxic and oxidative damage in rats. The animals used were broadly divided into four (A, B, C and D) experimental groups. Group A rats served as control animals and received distilled water intraperitoneally (n = 5). Groups B and C rats received intraperitoneal injections of permethrin (60 mg kg(-1) b.w) and olive leaf extract (500 mg kg(-1) b.w), respectively. Group D rats received permethrin (60 mg kg(-1) b.w) plus olive leaf extract (500 mg kg(-1) b.w). Rats were orally administered their respective feed daily for 21 days. At the end of the experiment rats were anesthetized and serum and bone marrow cell samples were obtained. Genotoxic damage was assessed by micronucleus and chromosomal aberration assays. Total antioxidant capacity and total oxidant status were also measured in serum samples to assess oxidative status. Treatment of Group B with permethrin resulted in genotoxic damage and increased total oxidant status levels. Permethrin treatment also significantly decreased (P < 0.05) total antioxidant capacity level when compared to Group A rats. Group C rats showed significant increases (P < 0.05) in total antioxidant capacity level and no alterations in cytogenetic parameters. Moreover, simultaneous treatments with olive leaf extract significantly modulated the toxic effects of permethrin in Group D rats. It can be concluded that olive leaf extract has beneficial influences and could be able to antagonize permethrin toxicity. As a result, this investigation clearly revealed the protective role of olive leaf extract against the genetic and oxidative damage by permethrin in vivo for the first time.
Similar articles
-
Aluminum phosphide-induced genetic and oxidative damages in rats: attenuation by Laurus nobilis leaf extract.Toxicol Ind Health. 2013 Aug;29(7):579-83. doi: 10.1177/0748233711433942. Epub 2012 Jan 31. Toxicol Ind Health. 2013. PMID: 22294441
-
Olive (Olea europaea L.) leaf extract counteracts genotoxicity and oxidative stress of permethrin in human lymphocytes.J Toxicol Sci. 2011 Oct;36(5):531-7. doi: 10.2131/jts.36.531. J Toxicol Sci. 2011. PMID: 22008529
-
Olive oil and leaf extract prevent fluoxetine-induced hepatotoxicity by attenuating oxidative stress, inflammation and apoptosis.Biomed Pharmacother. 2018 Feb;98:446-453. doi: 10.1016/j.biopha.2017.12.101. Epub 2017 Dec 27. Biomed Pharmacother. 2018. PMID: 29278855
-
Olive leaf extract modulates glycerol-induced kidney and liver damage in rats.Environ Sci Pollut Res Int. 2020 Jun;27(17):22100-22111. doi: 10.1007/s11356-020-08371-6. Epub 2020 Apr 15. Environ Sci Pollut Res Int. 2020. PMID: 32291641
-
Permethrin-induced oxidative stress and toxicity and metabolism. A review.Environ Res. 2016 Aug;149:86-104. doi: 10.1016/j.envres.2016.05.003. Epub 2016 May 14. Environ Res. 2016. PMID: 27183507 Review.
Cited by
-
The effect of carvacrol on healthy neurons and N2a cancer cells: some biochemical, anticancerogenicity and genotoxicity studies.Cytotechnology. 2014 Jan;66(1):149-57. doi: 10.1007/s10616-013-9547-5. Epub 2013 Apr 4. Cytotechnology. 2014. PMID: 23553016 Free PMC article.
-
Cytotoxicity of some edible mushrooms extracts over liver hepatocellular carcinoma cells in conjunction with their antioxidant and antibacterial properties.Pharmacogn Mag. 2015 May;11(Suppl 1):S6-S18. doi: 10.4103/0973-1296.157665. Pharmacogn Mag. 2015. PMID: 26109775 Free PMC article.
-
Cytotoxicity and genotoxicity of zingiberene on different neuron cell lines in vitro.Cytotechnology. 2015 Dec;67(6):939-46. doi: 10.1007/s10616-014-9729-9. Epub 2014 May 7. Cytotechnology. 2015. PMID: 24801579 Free PMC article.
-
Olive leaf extract inhibits lead poisoning-induced brain injury.Neural Regen Res. 2013 Aug 5;8(22):2021-9. doi: 10.3969/j.issn.1673-5374.2013.22.001. Neural Regen Res. 2013. PMID: 25206510 Free PMC article.
-
Microbiological and Antioxidant Activity of Phenolic Compounds in Olive Leaf Extract.Molecules. 2020 Dec 15;25(24):5946. doi: 10.3390/molecules25245946. Molecules. 2020. PMID: 33334001 Free PMC article. Review.
References
-
- Benavente-García O, Castillo J, Lorente J, Alcaraz M. Radioprotective effects in vivo of phenolics extracted from Olea europaea L. leaves against X-ray-induced chromosomal damage: comparative study versus several flavonoids and sulfur-containing compounds. J Med Food. 2002;5:125–135. doi: 10.1089/10966200260398152. - DOI - PubMed
LinkOut - more resources
Full Text Sources
Research Materials