Is human cytomegalovirus a target in cancer therapy?

doi:10.18632/oncotarget.383

Review

. 2011 Dec;2(12):1329-38.

doi: 10.18632/oncotarget.383.

Is human cytomegalovirus a target in cancer therapy?

John Inge Johnsen¹, Ninib Baryawno, Cecilia Söderberg-Nauclér

Affiliations

PMID: 22246171
PMCID: PMC3282090
DOI: 10.18632/oncotarget.383

Review

Is human cytomegalovirus a target in cancer therapy?

John Inge Johnsen et al. Oncotarget. 2011 Dec.

. 2011 Dec;2(12):1329-38.

doi: 10.18632/oncotarget.383.

Authors

John Inge Johnsen¹, Ninib Baryawno, Cecilia Söderberg-Nauclér

Affiliation

¹ Childhood Cancer Research Unit, Department of Women´s and Children´s Health, Karolinska Institute, 171 76 Stockholm, Sweden. joinjo@ki.se

PMID: 22246171
PMCID: PMC3282090
DOI: 10.18632/oncotarget.383

Abstract

Human cytomegalovirus (HCMV) is a herpesvirus that is prevalent in the human population. HCMV has recently been implicated in different cancer forms where it may provide mechanisms for oncogenic transformation, oncomodulation and tumour cell immune evasion. Moreover, antiviral treatment against HCMV has been shown to inhibit tumour growth in preclinical models. Here we describe the possible involvement of HCMV in cancer and discuss the potential molecular impact expression of HCMV proteins have on tumour cells and the surrounding tumour microenvironment.

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References

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1. Scheurer ME, Bondy ML, Aldape KD, Albrecht T, El-Zein R. Detection of human cytomegalovirus in different histological types of gliomas. Acta Neuropathol. 2008;116(1):79–86. - PMC - PubMed

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[1] Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008;454(7203):436–444. - PubMed

[2] Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008;454(7203):436–444. - PubMed

[3] Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646–674. - PubMed

[4] Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646–674. - PubMed

[5] Zur Hausen H. The search for infectious causes of human cancers: where and why. Virology. 2009;392(1):1–10. - PubMed

[6] Zur Hausen H. The search for infectious causes of human cancers: where and why. Virology. 2009;392(1):1–10. - PubMed

[7] Straat K, Liu C, Rahbar A, Zhu Q, Liu L, Wolmer-Solberg N, Lou F, Liu Z, Shen J, Jia J, et al. Activation of telomerase by human cytomegalovirus. J Natl Cancer Inst. 2009;101(7):488–497. - PubMed

[8] Straat K, Liu C, Rahbar A, Zhu Q, Liu L, Wolmer-Solberg N, Lou F, Liu Z, Shen J, Jia J, et al. Activation of telomerase by human cytomegalovirus. J Natl Cancer Inst. 2009;101(7):488–497. - PubMed

[9] Scheurer ME, Bondy ML, Aldape KD, Albrecht T, El-Zein R. Detection of human cytomegalovirus in different histological types of gliomas. Acta Neuropathol. 2008;116(1):79–86. - PMC - PubMed

[10] Scheurer ME, Bondy ML, Aldape KD, Albrecht T, El-Zein R. Detection of human cytomegalovirus in different histological types of gliomas. Acta Neuropathol. 2008;116(1):79–86. - PMC - PubMed

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Is human cytomegalovirus a target in cancer therapy?

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Is human cytomegalovirus a target in cancer therapy?

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