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. 2011 Dec 23;42(1):122.
doi: 10.1186/1297-9716-42-122.

Virulence of Newcastle disease virus: what is known so far?

Jos C F M Dortmans  1 , Guus Koch, Peter J M Rottier, Ben P H Peeters
Affiliations

Virulence of Newcastle disease virus: what is known so far?

Jos C F M Dortmans et al. Vet Res. .

Abstract

In the last decade many studies have been performed on the virulence of Newcastle disease virus (NDV). This is mainly due to the development of reverse genetics systems which made it possible to genetically modify NDV and to investigate the contribution of individual genes and genome regions to its virulence. However, the available information is scattered and a comprehensive overview of the factors and conditions determining NDV virulence is lacking. This review summarises, compares and discusses the available literature and shows that virulence of NDV is a complex trait determined by multiple genetic factors.

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Figures

Figure 1
Figure 1
Summary of the contribution of individual NDV proteins to virulence based on a compilation of the data shown in Tables 1 to 5. The error bars show standard deviations.
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