What is different about serotype 1 pneumococci?
- PMID: 22191445
- DOI: 10.2217/fmb.11.146
What is different about serotype 1 pneumococci?
Abstract
Serotype 1 Streptococcus pneumoniae is among the most commonly isolated serotype in invasive pneumococcal disease but is rarely found causing asymptomatic nasopharyngeal colonization. Compared to infection by other serotypes, infection caused by serotype 1 is more likely to be identified in young patients without comorbidities but is generally associated with a lower mortality. Empyema and extrapulmonary manifestations are common. Outbreaks of serotype 1 disease have been reported in closed communities and epidemics are particularly common in sub-Saharan Africa. The serotype 1 capsular polysaccharide is a zwitterionic structure that enables it to function as a T-cell dependent antigen under some circumstances, in contrast to other pneumococcal capsular polysaccharides that are T-cell independent antigens. There are also differences in the key virulence factor pneumolysin in some serotype 1 isolates. The clinical significance of these differences remains to be determined.
Similar articles
-
The immunising effect of pneumococcal nasopharyngeal colonisation; protection against future colonisation and fatal invasive disease.Immunobiology. 2010 Apr;215(4):251-63. doi: 10.1016/j.imbio.2009.12.004. Epub 2009 Dec 28. Immunobiology. 2010. PMID: 20071053
-
Presence of nonhemolytic pneumolysin in serotypes of Streptococcus pneumoniae associated with disease outbreaks.J Infect Dis. 2007 Sep 15;196(6):936-44. doi: 10.1086/520091. Epub 2007 Aug 6. J Infect Dis. 2007. PMID: 17703426
-
The capsular serotype of Streptococcus pneumoniae is more important than the genetic background for resistance to complement.Infect Immun. 2010 Dec;78(12):5262-70. doi: 10.1128/IAI.00740-10. Epub 2010 Sep 20. Infect Immun. 2010. PMID: 20855513 Free PMC article.
-
Pneumococcal vaccines: mechanism of action, impact on epidemiology and adaption of the species.Int J Antimicrob Agents. 2008 Sep;32(3):199-206. doi: 10.1016/j.ijantimicag.2008.01.021. Epub 2008 Apr 18. Int J Antimicrob Agents. 2008. PMID: 18378430 Review.
-
Impact of pneumococcal conjugate vaccine on infections caused by antibiotic-resistant Streptococcus pneumoniae.Clin Microbiol Infect. 2009 Apr;15 Suppl 3:16-20. doi: 10.1111/j.1469-0691.2009.02726.x. Clin Microbiol Infect. 2009. PMID: 19366365 Review.
Cited by
-
Current concepts in host-microbe interaction leading to pneumococcal pneumonia.Curr Opin Infect Dis. 2013 Jun;26(3):277-83. doi: 10.1097/QCO.0b013e3283608419. Curr Opin Infect Dis. 2013. PMID: 23571695 Free PMC article. Review.
-
Construction of a pneumolysin deficient mutant in streptococcus pneumoniae serotype 1 strain 519/43 and phenotypic characterisation.Microb Pathog. 2020 Apr;141:103999. doi: 10.1016/j.micpath.2020.103999. Epub 2020 Jan 26. Microb Pathog. 2020. PMID: 31996316 Free PMC article.
-
Population genetic structure, antibiotic resistance, capsule switching and evolution of invasive pneumococci before conjugate vaccination in Malawi.Vaccine. 2017 Aug 16;35(35 Pt B):4594-4602. doi: 10.1016/j.vaccine.2017.07.009. Epub 2017 Jul 12. Vaccine. 2017. PMID: 28711389 Free PMC article.
-
Determination of pneumococcal serotypes in meningitis cases in Niger, 2003-2011.PLoS One. 2013;8(3):e60432. doi: 10.1371/journal.pone.0060432. Epub 2013 Mar 28. PLoS One. 2013. PMID: 23555971 Free PMC article.
-
Clinical implications of pneumococcal serotypes: invasive disease potential, clinical presentations, and antibiotic resistance.J Korean Med Sci. 2013 Jan;28(1):4-15. doi: 10.3346/jkms.2013.28.1.4. Epub 2013 Jan 8. J Korean Med Sci. 2013. PMID: 23341706 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
