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. 2011 Sep 1;6(3):314-319.
doi: 10.2174/157436211797483949.

Neurogenesis in Alzheimer´s disease: a realistic alternative to neuronal degeneration?

Rocío E Gonzalez-Castaneda  1 , Alma Y Galvez-Contreras, Sonia Luquín, Oscar Gonzalez-Perez
Affiliations

Neurogenesis in Alzheimer´s disease: a realistic alternative to neuronal degeneration?

Rocío E Gonzalez-Castaneda et al. Curr Signal Transduct Ther. .

Abstract

Neural stem cells (NSC) are cells that have the capacity to generate multiple types of differentiated brain cells. In conditions in which there is a loss of key functional cell groups, such as neurons, inducing or introducing neural stem cells to replace the function of those cells that were lost during the disease has the greatest potential therapeutic applications. Indeed, the achievement of one of the main objectives of various investigations is already on the horizon for some conditions, such as Alzheimer's disease. It is not known whether impaired neurogenesis contributes to neuronal depletion and cognitive dysfunction in Alzheimer's disease (AD). The results of the different investigations are controversial; some studies have found that neurogenesis is increased in AD brains, but others have not.

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Figures

Figure 1
Figure 1
Mechanisms of neurodegeneration in AD. Defective cellular and genetic processes can lead to different defects, synaptic damage and cell death.
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