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Review
. 2012 Jan:182:3-11.
doi: 10.1016/j.plantsci.2010.11.014. Epub 2010 Dec 7.

Structural insights into PYR/PYL/RCAR ABA receptors and PP2Cs

Julia Santiago  1 , Florine Dupeux, Katja Betz, Regina Antoni, Miguel Gonzalez-Guzman, Lesia Rodriguez, José Antonio Márquez, Pedro L Rodriguez
Affiliations
Free article
Review

Structural insights into PYR/PYL/RCAR ABA receptors and PP2Cs

Julia Santiago et al. Plant Sci. 2012 Jan.
Free article

Abstract

Abscisic acid (ABA) plays an essential function in plant physiology since it is required for biotic and abiotic stress responses as well as control of plant growth and development. A new family of soluble ABA receptors, named PYR/PYL/RCAR, has emerged as ABA sensors able to inhibit the activity of specific protein phosphatases type-2C (PP2Cs) in an ABA-dependent manner. The structural and functional mechanism by which ABA is perceived by these receptors and consequently leads to inhibition of the PP2Cs has been recently elucidated. The module PYR/PYL/RCAR-ABA-PP2C offers an elegant and unprecedented mechanism to control phosphorylation signaling cascades in a ligand-dependent manner. The knowledge of their three-dimensional structures paves the way to the design of ABA agonists able to modulate the plant stress response.

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