Keeping STATs on memory CD8+ T cells
- PMID: 22118521
- DOI: 10.1016/j.immuni.2011.11.006
Keeping STATs on memory CD8+ T cells
Abstract
The CD8(+) T cell response is characterized by generation of a population of effector cells and establishment of a persistent memory pool. In this issue, Cui et al. (2011) and Siegel et al. (2011) show that cytokine receptor signaling through the transcription factor STAT3 establishes stable memory CD8(+) T cells.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
-
An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells.Immunity. 2011 Nov 23;35(5):792-805. doi: 10.1016/j.immuni.2011.09.017. Immunity. 2011. PMID: 22118527 Free PMC article.
-
A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory.Immunity. 2011 Nov 23;35(5):806-18. doi: 10.1016/j.immuni.2011.09.016. Immunity. 2011. PMID: 22118528 Free PMC article.
Similar articles
-
Signal-transducing adaptor protein-2 promotes generation of functional long-term memory CD8+ T cells by preventing terminal effector differentiation.Oncotarget. 2017 May 9;8(19):30766-30780. doi: 10.18632/oncotarget.15403. Oncotarget. 2017. PMID: 28430604 Free PMC article.
-
Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory.Proc Natl Acad Sci U S A. 2010 May 25;107(21):9777-82. doi: 10.1073/pnas.0914127107. Epub 2010 May 10. Proc Natl Acad Sci U S A. 2010. PMID: 20457902 Free PMC article.
-
Signal integration by Akt regulates CD8 T cell effector and memory differentiation.J Immunol. 2012 May 1;188(9):4305-14. doi: 10.4049/jimmunol.1103568. Epub 2012 Mar 30. J Immunol. 2012. PMID: 22467649 Free PMC article.
-
Signals required for programming effector and memory development by CD8+ T cells.Immunol Rev. 2006 Jun;211:81-92. doi: 10.1111/j.0105-2896.2006.00382.x. Immunol Rev. 2006. PMID: 16824119 Review.
-
Requirements for CD8 T-cell priming, memory generation and maintenance.Curr Opin Immunol. 2007 Jun;19(3):315-9. doi: 10.1016/j.coi.2007.04.010. Epub 2007 Apr 12. Curr Opin Immunol. 2007. PMID: 17433873 Review.
Cited by
-
Leptin-based adjuvants: an innovative approach to improve vaccine response.Vaccine. 2013 Mar 25;31(13):1666-72. doi: 10.1016/j.vaccine.2013.01.032. Epub 2013 Jan 29. Vaccine. 2013. PMID: 23370154 Free PMC article. Review.
-
CD8 T cell memory: it takes all kinds.Front Immunol. 2012 Nov 27;3:353. doi: 10.3389/fimmu.2012.00353. eCollection 2012. Front Immunol. 2012. PMID: 23230436 Free PMC article.
-
STAT3 Dysregulation in Mature T and NK Cell Lymphomas.Cancers (Basel). 2019 Nov 2;11(11):1711. doi: 10.3390/cancers11111711. Cancers (Basel). 2019. PMID: 31684088 Free PMC article. Review.
-
A multiepitope of XBP1, CD138 and CS1 peptides induces myeloma-specific cytotoxic T lymphocytes in T cells of smoldering myeloma patients.Leukemia. 2015 Jan;29(1):218-29. doi: 10.1038/leu.2014.159. Epub 2014 May 14. Leukemia. 2015. PMID: 24935722 Free PMC article.
-
Complexity and Controversies over the Cytokine Profiles of T Helper Cell Subpopulations in Tuberculosis.J Immunol Res. 2015;2015:639107. doi: 10.1155/2015/639107. Epub 2015 Oct 1. J Immunol Res. 2015. PMID: 26495323 Free PMC article. Review.
Publication types
Grants and funding
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous