Development. Inheriting maternal mtDNA

doi:10.1126/science.1215480

Comment

. 2011 Nov 25;334(6059):1069-70.

doi: 10.1126/science.1215480.

Development. Inheriting maternal mtDNA

Beth Levine¹, Zvulun Elazar

Affiliations

Affiliation

¹ Center for Autophagy Research, Department of Internal Medicine, Department of Microbiology, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9113, USA. beth.levine@utsouthwestern.edu

PMID: 22116870
PMCID: PMC3518432
DOI: 10.1126/science.1215480

Comment

Development. Inheriting maternal mtDNA

Beth Levine et al. Science. 2011.

. 2011 Nov 25;334(6059):1069-70.

doi: 10.1126/science.1215480.

Authors

Beth Levine¹, Zvulun Elazar

Affiliation

¹ Center for Autophagy Research, Department of Internal Medicine, Department of Microbiology, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9113, USA. beth.levine@utsouthwestern.edu

PMID: 22116870
PMCID: PMC3518432
DOI: 10.1126/science.1215480

No abstract available

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Figures

**Figure 1. Selective autophagy of paternal mitochondria**
(A) The *C. elegans* hermaphrodite reproductive tract is shown. (B) Fusion of sperm and oocyte in the *C. elegans* spermatheca transfers the paternal nucleus, membranous organelles (MOs), and mitochondria to the (C) cytoplasm of the fertilized oocyte. MOs in the vicinity of the paternal mitochondria are labeled with ubiquitin (Ub) chains for degradation. Both MOs and paternal mitochondria are selectively recruited to autophagosomes (LGG-1/2–labeled membranes), which fuse with lysosomes.

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Comment on

Degradation of paternal mitochondria by fertilization-triggered autophagy in C. elegans embryos.
Sato M, Sato K. Sato M, et al. Science. 2011 Nov 25;334(6059):1141-4. doi: 10.1126/science.1210333. Epub 2011 Oct 13. Science. 2011. PMID: 21998252
Postfertilization autophagy of sperm organelles prevents paternal mitochondrial DNA transmission.
Al Rawi S, Louvet-Vallée S, Djeddi A, Sachse M, Culetto E, Hajjar C, Boyd L, Legouis R, Galy V. Al Rawi S, et al. Science. 2011 Nov 25;334(6059):1144-7. doi: 10.1126/science.1211878. Epub 2011 Oct 27. Science. 2011. PMID: 22033522

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References

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1. Sato M, Sato K. Science. 2011;334:1141. - PubMed
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1. Nishimura Y, et al. Proc. Natl. Acad. Sci. U.S.A. 2006;103:1382. - PubMed

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[1] Ankel-Simons F, Cummins JM. Proc. Natl. Acad. Sci. U.S.A. 1996;93:13859. - PMC - PubMed

[2] Ankel-Simons F, Cummins JM. Proc. Natl. Acad. Sci. U.S.A. 1996;93:13859. - PMC - PubMed

[3] Sato M, Sato K. Science. 2011;334:1141. - PubMed

[4] Sato M, Sato K. Science. 2011;334:1141. - PubMed

[5] Al Rawi S, et al. Science. 2011;334:1144. - PubMed

[6] Al Rawi S, et al. Science. 2011;334:1144. - PubMed

[7] Weidberg H, Shvets E, Elazar Z. Annu. Rev. Biochem. 2011;80:125. - PubMed

[8] Weidberg H, Shvets E, Elazar Z. Annu. Rev. Biochem. 2011;80:125. - PubMed

[9] Nishimura Y, et al. Proc. Natl. Acad. Sci. U.S.A. 2006;103:1382. - PubMed

[10] Nishimura Y, et al. Proc. Natl. Acad. Sci. U.S.A. 2006;103:1382. - PubMed

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Development. Inheriting maternal mtDNA

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Development. Inheriting maternal mtDNA

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