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Review
. 2012 May;107(3):463-77.
doi: 10.1007/s11060-011-0765-4. Epub 2011 Nov 24.

Targeting DNA repair and the cell cycle in glioblastoma

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Review

Targeting DNA repair and the cell cycle in glioblastoma

Brian M Alexander et al. J Neurooncol. 2012 May.

Abstract

Glioblastoma is a disease with poor outcomes despite standard therapy. Specific targeting of the DNA damage response is a strategy that is becoming increasingly employed in oncology and has intriguing potential for improving outcomes in glioblastoma. DNA damage targeting has implications for improving current therapy as well as the potential to leverage inherent differences in glioblastoma cells to widen the therapeutic window.

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