Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2011 Nov 7;17(11):1410-22.
doi: 10.1038/nm.2538.

Atherosclerosis: current pathogenesis and therapeutic options

Christian Weber  1 , Heidi Noels
Affiliations
Review

Atherosclerosis: current pathogenesis and therapeutic options

Christian Weber et al. Nat Med. .

Abstract

Coronary artery disease (CAD) arising from atherosclerosis is a leading cause of death and morbidity worldwide. The underlying pathogenesis involves an imbalanced lipid metabolism and a maladaptive immune response entailing a chronic inflammation of the arterial wall. The disturbed equilibrium of lipid accumulation, immune responses and their clearance is shaped by leukocyte trafficking and homeostasis governed by chemokines and their receptors. New pro- and anti-inflammatory pathways linking lipid and inflammation biology have been discovered, and genetic profiling studies have unveiled variations involved in human CAD. The growing understanding of the inflammatory processes and mediators has uncovered an intriguing diversity of targetable mechanisms that can be exploited to complement lipid-lowering therapies. Here we aim to systematically survey recently identified molecular mechanisms, translational developments and clinical strategies for targeting lipid-related inflammation in atherosclerosis and CAD.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Circulation. 2011 Mar 15;123(10):1083-91 - PubMed
    1. J Clin Invest. 2011 Jul;121(7):2898-910 - PubMed
    1. J Clin Invest. 2011 May;121(5):2025-36 - PubMed
    1. Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):1858-63 - PubMed
    1. Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):251-7 - PubMed

Publication types

MeSH terms

LinkOut - more resources