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Review
. 1990 Sep-Nov;236(2-3):277-87.
doi: 10.1016/0921-8777(90)90011-s.

Eukaryotic DNA ligases

D D Lasko  1 , A E Tomkinson, T Lindahl
Affiliations
Review

Eukaryotic DNA ligases

D D Lasko et al. Mutat Res. 1990 Sep-Nov.

Abstract

Recent studies on eukaryotic DNA ligases are briefly reviewed. The two distinguishable enzymes from mammalian cells, DNA ligase I and DNA ligase II, have been purified to homogeneity and characterized biochemically. Two distinct DNA ligases have also been identified in Drosophila melanogaster embryos. The genes encoding DNA ligases from Schizosaccharomyces pombe, Saccharomyces cerevisiae and vaccinia virus have been cloned and sequenced. These 3 proteins exhibit about 30% amino acid sequence identity; the 2 yeast enzymes share 53% amino acid sequence identity or conserved changes. Altered DNA ligase I activity has been found in cell lines from patients with Bloom's syndrome, although a causal link between the enzyme deficiency and the disease has not yet been proven.

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