doi: 10.1111/j.1600-0560.1990.tb00085.x.
Immunocompetent cells and epithelial cell modifications in molluscum contagiosum
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- PMID: 2203834
- DOI: 10.1111/j.1600-0560.1990.tb00085.x
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Immunocompetent cells and epithelial cell modifications in molluscum contagiosum
J Cutan Pathol.
1990 Aug.
Abstract
We studied lesions of molluscum contagiosum with a panel of monoclonal antibodies to determine the phenotype of infiltrating cells and antigen modifications of infected keratinocytes. Our data indicate (1) a complete lack of immunocompetent cells in the viral lesions, and simultaneously a loss of B2-microglobulin reactivity by molluscum bodies, a cellular activation of EGF and transferrin receptors and expression of CD36 antigen of these bodies; (2) a moderate infiltrate of activated T cells and monocytes in the underlying epidermis; (3) an increase of Langerhans cell density and a CD36 expression by the surface of upper layer keratinocytes in the perilesional epidermis.
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