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. 2011 Sep;3(9):1624-33.
doi: 10.3390/v3091624. Epub 2011 Sep 5.

Restricted access to myeloid cells explained

Vicente Planelles  1
Affiliations

Restricted access to myeloid cells explained

Vicente Planelles. Viruses. 2011 Sep.

Abstract

The lentiviral accessory protein, Vpx, is known to counteract a restriction factor that is specific to myeloid cells, such as macrophages and dendritic cells. This review summarizes the findings in two seminal studies that identify SAMHD1 as the cellular protein that is responsible for myeloid cell restriction, and establish the existence of other types of restriction in these cells.

Keywords: Cullin4; DCAF-1; HIV; SAMHD1; SIV; Vpx; dendritic cell; macrophage; myeloid cell; ubiquitin.

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Figures

Figure 1.
Figure 1.
Genetic structure of HIV-1 and SIVsmm/SIVmac/HIV-2.
Figure 2.
Figure 2.
Proposed model for the ubiquitin ligase complex responsible for putative ubiquitination of SAMHD1. Adapted from [25].
See this image and copyright information in PMC

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