Determinants of bone mineral density in stable kidney transplant recipients
- PMID: 21928224
- DOI: 10.5301/jn.5000015
Determinants of bone mineral density in stable kidney transplant recipients
Abstract
Background: Kidney transplant recipients (KTR) are at increased risk for bone loss. Determinants of bone mineral density (BMD) in an unselected KTR population have not previously been described.
Methods: We conducted a cross-sectional analysis of 389 stable KTRs undergoing bone mineral densitometry assessment by dual-energy X-ray absorptiometry at the lumbar spine, total hip and femoral neck. Risk factors for osteopenia and osteoporosis were determined by t-tests or ANOVA and chi-square analysis as appropriate. Factors associated with reduced BMD were ascertained using multivariate linear regression.
Results: At the lumbar spine, 247 demonstrated normal BMD, 115 had osteopenia and 27 osteoporosis. Corresponding prevalence rates for the total hip and femoral neck were 222/143/24 and 178/184/27, respectively. Osteopenia or osteoporosis was more prevalent at the femoral neck than lumbar spine (p=0.002). Osteopenia or osteoporosis at the spine, hip and femoral neck were highly correlated (p<0.0001). Independent associations with reduced BMD included female sex (p<0.0001) and lower body mass index (p<0.0001) at all sites, age for total hip and femoral neck (p=0.0001), and hyperparathyroidism (p=0.036), time posttransplant (p=0.0001) for the femoral neck, with no association by renal function or 25-OH vitamin D level at any site.
Conclusions: Significant bone loss in KTRs is most prevalent at the femoral neck. Identifying risk factors for specific sites may allow for earlier intervention prior to osteoporosis development.
Similar articles
-
Loss of bone mineral density in renal transplantation recipients.Transplant Proc. 2010 Nov;42(9):3550-3. doi: 10.1016/j.transproceed.2010.07.106. Transplant Proc. 2010. PMID: 21094813
-
Prevalence and characteristics of bone disease in cirrhotic patients under evaluation for liver transplantation.Transplant Proc. 2012 Jul-Aug;44(6):1496-8. doi: 10.1016/j.transproceed.2012.05.011. Transplant Proc. 2012. PMID: 22841194
-
Age, body mass index, and serum prostate-specific antigen correlate with bone loss in men with prostate cancer not receiving androgen deprivation therapy.Urology. 2004 Aug;64(2):335-40. doi: 10.1016/j.urology.2004.03.036. Urology. 2004. PMID: 15302490
-
Bisphosphonates for prevention of osteopenia in kidney-transplant recipients: a systematic review of randomized controlled trials.Osteoporos Int. 2016 May;27(5):1683-90. doi: 10.1007/s00198-015-3465-7. Epub 2016 Jan 5. Osteoporos Int. 2016. PMID: 26733377 Review.
-
Bone mineral density is decreased in fibromyalgia syndrome: a systematic review and meta-analysis.Rheumatol Int. 2017 Apr;37(4):617-622. doi: 10.1007/s00296-016-3625-x. Epub 2016 Dec 5. Rheumatol Int. 2017. PMID: 27921150 Review.
Cited by
-
Current Status of Research on Osteoporosis after Solid Organ Transplantation: Pathogenesis and Management.Biomed Res Int. 2015;2015:413169. doi: 10.1155/2015/413169. Epub 2015 Nov 15. Biomed Res Int. 2015. PMID: 26649301 Free PMC article. Review.
-
Relation of testosterone level and other factors with bone mineral density in male kidney transplant recipients: a cross-sectional study.BMC Nephrol. 2023 Sep 14;24(1):271. doi: 10.1186/s12882-023-03318-8. BMC Nephrol. 2023. PMID: 37710199 Free PMC article.
-
Inverse relationship of bone mineral density and serum level of N-terminal pro-B-type natriuretic peptide in peritoneal dialysis patients.Tzu Chi Med J. 2016 Apr-Jun;28(2):68-72. doi: 10.1016/j.tcmj.2016.03.003. Epub 2016 May 28. Tzu Chi Med J. 2016. PMID: 28757725 Free PMC article.
-
Early steroid withdrawal has a positive effect on bone in kidney transplant recipients: a propensity score study with inverse probability-of-treatment weighting.Ther Adv Musculoskelet Dis. 2020 Oct 29;12:1759720X20953357. doi: 10.1177/1759720X20953357. eCollection 2020. Ther Adv Musculoskelet Dis. 2020. PMID: 33193832 Free PMC article.
-
Bone Density Reduction and Its Associated Factors in Kidney Transplant Recipients: A Cross-Sectional Study.Int J Organ Transplant Med. 2022;13(1):5-11. Int J Organ Transplant Med. 2022. PMID: 37383422 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Medical