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Review
. 2013 Jan;33(1):190-234.
doi: 10.1002/med.20252. Epub 2011 Sep 15.

On the selectivity and efficacy of defense peptides with respect to cancer cells

Frederick Harris  1 , Sarah R Dennison, Jaipaul Singh, David A Phoenix
Affiliations
Review

On the selectivity and efficacy of defense peptides with respect to cancer cells

Frederick Harris et al. Med Res Rev. 2013 Jan.

Abstract

Here, we review potential determinants of the anticancer efficacy of innate immune peptides (ACPs) for cancer cells. These determinants include membrane-based factors, such as receptors, phosphatidylserine, sialic acid residues, and sulfated glycans, and peptide-based factors, such as residue composition, sequence length, net charge, hydrophobic arc size, hydrophobicity, and amphiphilicity. Each of these factors may contribute to the anticancer action of ACPs, but no single factor(s) makes an overriding contribution to their overall selectivity and toxicity. Differences between the anticancer actions of ACPs seem to relate to different levels of interplay between these peptide and membrane-based factors.

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