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. 2011 Oct 15;21(20):6036-41.
doi: 10.1016/j.bmcl.2011.08.077. Epub 2011 Aug 22.

Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities

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Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities

Soon Young Shin et al. Bioorg Med Chem Lett. .

Abstract

It has been previously shown that some flavonoids inhibit NF-κB; however, the structure-activity relationships between chalcone, flavanone, flavone, and isoflavone derivatives and their TNFα induced NF-κB inhibitory effects on HCT116 human colon cancer cells have not yet been reported. Therefore, in this study, the effects of flavonoid structure on inhibition of NF-κB were investigated. Based on the combined results of this study, the structure of the flavonoids was shown to affect NF-κB activation.

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