Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities
- PMID: 21907578
- DOI: 10.1016/j.bmcl.2011.08.077
Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities
Abstract
It has been previously shown that some flavonoids inhibit NF-κB; however, the structure-activity relationships between chalcone, flavanone, flavone, and isoflavone derivatives and their TNFα induced NF-κB inhibitory effects on HCT116 human colon cancer cells have not yet been reported. Therefore, in this study, the effects of flavonoid structure on inhibition of NF-κB were investigated. Based on the combined results of this study, the structure of the flavonoids was shown to affect NF-κB activation.
Copyright © 2011 Elsevier Ltd. All rights reserved.
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