Comparative pharmacokinetics of perfluorooctanesulfonate (PFOS) in rats, mice, and monkeys
- PMID: 21889587
- DOI: 10.1016/j.reprotox.2011.07.002
Comparative pharmacokinetics of perfluorooctanesulfonate (PFOS) in rats, mice, and monkeys
Abstract
Perfluorooctanesulfonate (PFOS) has been found in biological samples in wildlife and humans. The geometric mean half-life of serum elimination of PFOS in humans has been estimated to be 4.8 years (95% CI, 4.0-5.8). A series of studies was undertaken to establish pharmacokinetic parameters for PFOS in rats, mice, and monkeys after single oral and/or IV administration of K(+)PFOS. Animals were followed for up to 23 weeks, and pharmacokinetic parameters were determined by WinNonlin® software. Rats and mice appeared to be more effective at eliminating PFOS than monkeys. The serum elimination half-lives in the rodent species were on the order of 1-2 months; whereas, in monkeys, the serum elimination half lives approximated 4 months. Collectively, these studies provide valuable insight for human health risk assessment regarding the potential for accumulation of body burden in humans on repeated exposure to PFOS and PFOS-generating materials.
Copyright © 2011 Elsevier Inc. All rights reserved.
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