Autoimmunity
- PMID: 21884890
- DOI: 10.1016/B978-0-12-385895-5.00006-2
Autoimmunity
Abstract
The scarcity of Trypanosoma cruzi in inflammatory lesions of chronic Chagas disease led early investigators to suggest that tissue damage had an autoimmune nature. In spite of parasite persistence in chronic Chagas disease, several reports indicate that inflammatory tissue damage may not be correlated to the local presence of T. cruzi. A significant number of reports have described autoantibodies and self-reactive T cells, often cross-reactive with T. cruzi antigens, both in patients and in animal models. Evidence for a direct pathogenetic role of autoimmunity was suggested by the development of lesions after immunization with T. cruzi antigens or passive transfer of lymphocytes from infected animals, and the amelioration of chronic myocarditis in animals made tolerant to myocardial antigens. Autoimmune and T. cruzi-specific innate or adaptative responses are not incompatible or mutually exclusive, and it is likely that a combination of both is involved in the pathogenesis of chronic Chagas disease cardiomyopathy. The association between persistent infection and autoimmune diseases-such as multiple sclerosis or diabetes mellitus-suggests that post-infectious autoimmunity may be a frequent finding. Here, we critically review evidence for autoimmune phenomena and their possible pathogenetic role in human Chagas disease and animal models, with a focus on chronic Chagas disease cardiomyopathy.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Similar articles
-
Trypanosoma cruzi-induced molecular mimicry and Chagas' disease.Curr Top Microbiol Immunol. 2005;296:89-123. doi: 10.1007/3-540-30791-5_6. Curr Top Microbiol Immunol. 2005. PMID: 16323421 Review.
-
Autoimmunity in Chagas' disease. Identification of cardiac myosin-B13 Trypanosoma cruzi protein crossreactive T cell clones in heart lesions of a chronic Chagas' cardiomyopathy patient.J Clin Invest. 1996 Oct 15;98(8):1709-12. doi: 10.1172/JCI118969. J Clin Invest. 1996. PMID: 8878420 Free PMC article.
-
The role of parasite persistence in pathogenesis of Chagas heart disease.Parasite Immunol. 2009 Nov;31(11):673-85. doi: 10.1111/j.1365-3024.2009.01108.x. Parasite Immunol. 2009. PMID: 19825107 Review.
-
Innate and acquired immunity in the pathogenesis of Chagas disease.Autoimmunity. 2004 Aug;37(5):399-409. doi: 10.1080/08916930410001713115. Autoimmunity. 2004. PMID: 15621564 Review.
-
Autoimmune pathogenesis of Chagas heart disease: looking back, looking ahead.Am J Pathol. 2015 Jun;185(6):1537-47. doi: 10.1016/j.ajpath.2014.12.023. Epub 2015 Apr 7. Am J Pathol. 2015. PMID: 25857229 Free PMC article. Review.
Cited by
-
IgG Autoantibodies Induced by T. cruzi During Pregnancy: Correlation with Gravidity Complications and Early Outcome Assessment of the Newborns.Matern Child Health J. 2016 Oct;20(10):2057-64. doi: 10.1007/s10995-016-2035-8. Matern Child Health J. 2016. PMID: 27318490
-
Visiting Molecular Mimicry Once More: Pathogenicity, Virulence, and Autoimmunity.Microorganisms. 2023 Jun 1;11(6):1472. doi: 10.3390/microorganisms11061472. Microorganisms. 2023. PMID: 37374974 Free PMC article.
-
BALB/c and C57BL/6 Mice Cytokine Responses to Trypanosoma cruzi Infection Are Independent of Parasite Strain Infectivity.Front Microbiol. 2018 Mar 26;9:553. doi: 10.3389/fmicb.2018.00553. eCollection 2018. Front Microbiol. 2018. PMID: 29662478 Free PMC article.
-
TcTASV-C, a protein family in Trypanosoma cruzi that is predominantly trypomastigote-stage specific and secreted to the medium.PLoS One. 2013 Jul 29;8(7):e71192. doi: 10.1371/journal.pone.0071192. Print 2013. PLoS One. 2013. PMID: 23923058 Free PMC article.
-
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.PLoS One. 2013 Nov 20;8(11):e79629. doi: 10.1371/journal.pone.0079629. eCollection 2013. PLoS One. 2013. PMID: 24324551 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
