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Review
. 2011 Jun;46(6):622-30.

[Advances in the structure-activity relationship study of natural flavonoids and its derivatives]

[Article in Chinese]
Jian-Qing Zhong  1 , Bo Li, Qi Jia, Yi-Ming Li, Wei-Liang Zhu, Kai-Xian Chen
Affiliations
  • PMID: 21882520
Review

[Advances in the structure-activity relationship study of natural flavonoids and its derivatives]

[Article in Chinese]
Jian-Qing Zhong et al. Yao Xue Xue Bao. 2011 Jun.

Abstract

Flavonoids are a large class of compounds widely distributed in nature. Many pharmacological activities of flavonoids have been reported such as anti-cancer, antioxidant, anti-inflammatory, hepatoprotective, antithrombotic, vasodilator, antiviral, antibacterial, antiallergic, and so on. In recent years, domestic and foreign research groups choose natural flavonoids and optimize their chemical structures in order to develop a number of new derivatives with stronger pharmacological activities. As part of the mechanisms are not clear, we need to strengthen in-depth research in the SAR (structure-activity relationship) study for targeted and efficient structure optimization. This paper systematically summarize current researches in the SAR studies of flavonoids and their derivatives, which can serve as a reference for synthesizing new flavonoid derivatives.

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