Review
doi: 10.1016/j.coi.2011.07.018.
Epub 2011 Aug 20.
Regulation of interleukin-10 and interleukin-22 expression in T helper cells
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- PMID: 21862302
- DOI: 10.1016/j.coi.2011.07.018
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Review
Regulation of interleukin-10 and interleukin-22 expression in T helper cells
Curr Opin Immunol.
2011 Oct.
Abstract
Interleukin (IL)-10 and IL-22 are crucial regulators of inflammation during immune responses. While IL-10 functions to prevent excessive inflammation by acting on immune cells, IL-22 elicits innate responses from tissue epithelia and promotes wound healing. Although T helper (Th) cells are a major source for both cytokines, IL-10 and IL-22 are rarely co-expressed at high levels in the same cells. Here we discuss a number of common aspects as well as crucial differences in the molecular regulation of both cytokines that might explain their broad, but distinct expression among Th cell subsets.
Copyright © 2011 Elsevier Ltd. All rights reserved.
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