Comparative pharmacokinetics of perfluorohexanesulfonate (PFHxS) in rats, mice, and monkeys

doi:10.1016/j.reprotox.2011.07.004

Comparative Study

. 2012 Jul;33(4):441-451.

doi: 10.1016/j.reprotox.2011.07.004. Epub 2011 Aug 11.

Comparative pharmacokinetics of perfluorohexanesulfonate (PFHxS) in rats, mice, and monkeys

Maria Sundström¹, Shu-Ching Chang², Patricia E Noker³, Gregory S Gorman⁴, Jill A Hart⁵, David J Ehresman⁶, Åke Bergman⁷, John L Butenhoff⁸

Affiliations

¹ Environmental Chemistry Unit, Department of Materials and Environmental Chemistry, Stockholm University, SE-106 91 Stockholm, Sweden. Electronic address: maria.sundstrom@mmk.su.se.
² Medical Department, 3M Company, St. Paul, MN 55144 United States. Electronic address: s.chang@mmm.com.
³ Southern Research Institute, Birmingham, AL 35255 United States. Electronic address: noker@southernresearch.org.
⁴ Southern Research Institute, Birmingham, AL 35255 United States; Samford University, Birmingham, AL 35229 United States. Electronic address: ggorman@samford.edu.
⁵ Medical Department, 3M Company, St. Paul, MN 55144 United States. Electronic address: jahart@mmm.com.
⁶ Medical Department, 3M Company, St. Paul, MN 55144 United States. Electronic address: djehresman@mmm.com.
⁷ Environmental Chemistry Unit, Department of Materials and Environmental Chemistry, Stockholm University, SE-106 91 Stockholm, Sweden. Electronic address: ake.bergman@mmk.su.se.
⁸ Medical Department, 3M Company, St. Paul, MN 55144 United States. Electronic address: jlbutenhoff@mmm.com.

PMID: 21856411
DOI: 10.1016/j.reprotox.2011.07.004

Comparative Study

Comparative pharmacokinetics of perfluorohexanesulfonate (PFHxS) in rats, mice, and monkeys

Maria Sundström et al. Reprod Toxicol. 2012 Jul.

. 2012 Jul;33(4):441-451.

doi: 10.1016/j.reprotox.2011.07.004. Epub 2011 Aug 11.

Authors

Maria Sundström¹, Shu-Ching Chang², Patricia E Noker³, Gregory S Gorman⁴, Jill A Hart⁵, David J Ehresman⁶, Åke Bergman⁷, John L Butenhoff⁸

Affiliations

¹ Environmental Chemistry Unit, Department of Materials and Environmental Chemistry, Stockholm University, SE-106 91 Stockholm, Sweden. Electronic address: maria.sundstrom@mmk.su.se.
² Medical Department, 3M Company, St. Paul, MN 55144 United States. Electronic address: s.chang@mmm.com.
³ Southern Research Institute, Birmingham, AL 35255 United States. Electronic address: noker@southernresearch.org.
⁴ Southern Research Institute, Birmingham, AL 35255 United States; Samford University, Birmingham, AL 35229 United States. Electronic address: ggorman@samford.edu.
⁵ Medical Department, 3M Company, St. Paul, MN 55144 United States. Electronic address: jahart@mmm.com.
⁶ Medical Department, 3M Company, St. Paul, MN 55144 United States. Electronic address: djehresman@mmm.com.
⁷ Environmental Chemistry Unit, Department of Materials and Environmental Chemistry, Stockholm University, SE-106 91 Stockholm, Sweden. Electronic address: ake.bergman@mmk.su.se.
⁸ Medical Department, 3M Company, St. Paul, MN 55144 United States. Electronic address: jlbutenhoff@mmm.com.

PMID: 21856411
DOI: 10.1016/j.reprotox.2011.07.004

Abstract

Perfluorohexanesulfonate (PFHxS) has been found in biological samples from wildlife and humans. The human geometric mean serum PFHxS elimination half-life has been estimated to be 2665days. A series of studies was undertaken to establish pharmacokinetic parameters for PFHxS in rats, mice, and monkeys after single administration with pharmacokinetic parameters determined by WinNonlin(®) software. Rats and mice appeared to be more effective at eliminating PFHxS than monkeys. With the exception of female rats, which had serum PFHxS elimination half-life of approximately 2 days, the serum elimination half-lives in the rodent species and monkeys approximated 1month and 4months, respectively, when followed over extended time periods (10-24weeks). Collectively, these studies provide valuable insight for human health risk assessment regarding the potential for accumulation of PFHxS in humans.

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Comparative pharmacokinetics of perfluorohexanesulfonate (PFHxS) in rats, mice, and monkeys

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Comparative pharmacokinetics of perfluorohexanesulfonate (PFHxS) in rats, mice, and monkeys

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