Resting state fMRI in Alzheimer's disease: beyond the default mode network
- PMID: 21813210
- DOI: 10.1016/j.neurobiolaging.2011.06.007
Resting state fMRI in Alzheimer's disease: beyond the default mode network
Abstract
Using resting state (RS) functional magnetic resonance imaging (fMRI), the connectivity patterns of the default mode (DMN), frontoparietal, executive, and salience networks were explored in 13 Alzheimer's disease (AD) patients, 12 amnestic mild cognitive impairment (aMCI) patients, and 13 healthy controls. Compared with controls and aMCI, AD was associated with opposing connectivity effects in the DMN (decreased) and frontal networks (enhanced). The only RS abnormality found in aMCI patients compared with controls was a precuneus connectivity reduction in the DMN. RS fMRI group differences were only partly related to gray matter atrophy. In AD patients, the mean executive network connectivity was positively associated with frontal-executive and language neuropsychological scores. These results suggest that AD is associated with an alteration of large-scale functional brain networks, which extends well beyond the DMN. In AD, the limited resources of the DMN may be paralleled, in an attempt to maintain cognitive efficiency, by an increased prefrontal connectivity. A medial parietal RS fMRI signal change seems to be present since the early phase of AD.
Copyright © 2012 Elsevier Inc. All rights reserved.
Similar articles
-
Functional network connectivity in the behavioral variant of frontotemporal dementia.Cortex. 2013 Oct;49(9):2389-401. doi: 10.1016/j.cortex.2012.09.017. Epub 2012 Oct 24. Cortex. 2013. PMID: 23164495
-
Detection of PCC functional connectivity characteristics in resting-state fMRI in mild Alzheimer's disease.Behav Brain Res. 2009 Jan 30;197(1):103-8. doi: 10.1016/j.bbr.2008.08.012. Epub 2008 Aug 22. Behav Brain Res. 2009. PMID: 18786570
-
Changes of intranetwork and internetwork functional connectivity in Alzheimer's disease and mild cognitive impairment.J Neural Eng. 2016 Aug;13(4):046008. doi: 10.1088/1741-2560/13/4/046008. Epub 2016 Jun 1. J Neural Eng. 2016. PMID: 27247279
-
Structural and functional network connectivity breakdown in Alzheimer’s disease studied with magnetic resonance imaging techniques.J Alzheimers Dis. 2011;24(3):455-74. doi: 10.3233/JAD-2011-101854. J Alzheimers Dis. 2011. PMID: 21297259 Review.
-
Dysregulation within the salience network and default mode network in hyperthyroid patients: a follow-up resting-state functional MRI study.Brain Imaging Behav. 2020 Feb;14(1):30-41. doi: 10.1007/s11682-018-9961-6. Brain Imaging Behav. 2020. PMID: 30259292 Review.
Cited by
-
Resting state fMRI in cluster headache: which role?Neurol Sci. 2015 May;36 Suppl 1:47-50. doi: 10.1007/s10072-015-2129-x. Neurol Sci. 2015. PMID: 26017511 Review.
-
Mapping the Progression of Atrophy in Early- and Late-Onset Alzheimer's Disease.J Alzheimers Dis. 2015;46(2):351-64. doi: 10.3233/JAD-142292. J Alzheimers Dis. 2015. PMID: 25737041 Free PMC article.
-
Atypical intrinsic neural timescale in the left angular gyrus in Alzheimer's disease.Brain Commun. 2024 Jul 11;6(4):fcae199. doi: 10.1093/braincomms/fcae199. eCollection 2024. Brain Commun. 2024. PMID: 38993284 Free PMC article.
-
Relationship between structural and functional connectivity change across the adult lifespan: A longitudinal investigation.Hum Brain Mapp. 2017 Jan;38(1):561-573. doi: 10.1002/hbm.23403. Epub 2016 Sep 22. Hum Brain Mapp. 2017. PMID: 27654880 Free PMC article.
-
TMS-EEG Co-Registration in Patients with Mild Cognitive Impairment, Alzheimer's Disease and Other Dementias: A Systematic Review.Brain Sci. 2021 Feb 27;11(3):303. doi: 10.3390/brainsci11030303. Brain Sci. 2021. PMID: 33673709 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical