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Review
. 2011 May 15;4(2):148-50.
Epub 2011 May 25.

Plasmatic markers in hemorrhagic stroke

I C Marginean  1 , D M Stanca, V Vacaras, O Soritau, M Margiean, D F Muresanu
Affiliations
Review

Plasmatic markers in hemorrhagic stroke

I C Marginean et al. J Med Life. .

Abstract

Stroke is the third most common cause of death in the United States and it is the leading cause of disability. Early diagnosis and immediate therapeutic interventions are important factors to reduce the extent of brain tissue damage and the risk of stroke-related death. A rapid blood test that can confirm the clinical or imaging diagnosis or that can add to the stratification of the risk would be very useful. Such a test has to be validated in large studies and has to be based on a simple and low-cost technology. Many biological markers were tested for their ability to serve as 'would-be' stroke biological markers; some of them appear to have a place in the diagnostic work-up of stroke patients. These molecules include Glial Fibrillary Acidic Protein (GFAP), the N-methyl-D-aspartate receptor (NMDA), APO C-III, APO C-I, PARK7, nucleoside diphosphate kinase A (NDKA), S100B, B-type neurotrophic growth factor, von Willebrand factor, matrix metalloproteinase-9, and monocyte chemotactic protein-1. There are obvious limitations to this study, among them the fact that disability does not necessarily correlate with the amount of cerebral tissue lost (the site of stroke may be more important) and the role of the blood-brain barrier in delaying the release of the neuronal proteins in the blood stream. Further studies are awaited to confirm the role of these molecules in the management of acute stroke patients.

Keywords: biomarker; diagnosis; hemorrhagic stroke; ischemic stroke; stroke.

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References

    1. Rosamond W, Flegal K. Heart disease and stroke statistics–2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee . Circulation . 2007;115:69–171. - PubMed
    1. European Stroke Initiative Recommendations for Stroke Management–update 2003. 2003;16:311–337. - PubMed
    1. Whiteley W, Tseng MC. Blood Biomarkers in the Diagnosis of Ischemic Stroke . Stroke. 2008;39:2902–2909. - PubMed
    1. Reynolds MA, Kirchick HJ. Clin. Chem. 2003;49:1733–1739. - PubMed
    1. Foerch C, Curdt I, Yan B, Moreau P. Serum glial fibrillary acidic protein as a biomarker for intracerebral haemorrhage in patients with acute stroke . J Neurol Neurosurg Psychiatry . 2006;77:181–184. - PMC - PubMed

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