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. 1990 Dec;137(6):1317-22.

Detection of HTLV-I proviral sequences in CD30-positive large cell cutaneous T-cell lymphomas

I Anagnostopoulos  1 , M Hummel, P Kaudewitz, H Herbst, O Braun-Falco, H Stein
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Detection of HTLV-I proviral sequences in CD30-positive large cell cutaneous T-cell lymphomas

I Anagnostopoulos et al. Am J Pathol. 1990 Dec.

Abstract

To investigate the possibility that cutaneous T-cell lymphomas of large cell type may be associated with human T-cell leukemia/lymphoma virus type I infection in nonendemic regions, tissue samples from six cases of large cell cutaneous T-cell lymphoma and four cases of small cell cutaneous T-cell lymphoma were screened for the presence of integrated proviral human T-cell leukemia/lymphoma virus type I DNA. Combined use of Southern blot hybridization and enzymatic DNA amplification revealed human T-cell leukemia/lymphoma virus type I-specific sequences in all cases of large cell cutaneous T-cell lymphoma and in none of the cases of small cell cutaneous T-cell lymphoma. These results suggest that in nonendemic areas, a significant proportion of large cell cutaneous T-cell lymphoma cases are associated with human T-cell leukemia/lymphoma virus type I.

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References

    1. Lancet. 1982 Mar 20;1(8273):639-43 - PubMed
    1. Nature. 1981 Nov 19;294(5838):268-71 - PubMed
    1. N Engl J Med. 1983 Aug 4;309(5):257-64 - PubMed
    1. J Histochem Cytochem. 1984 Feb;32(2):219-29 - PubMed
    1. Proc Natl Acad Sci U S A. 1984 Apr;81(8):2534-7 - PubMed

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