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. 1990 Nov;10(11):5857-64.
doi: 10.1128/mcb.10.11.5857-5864.1990.

Differential effects of the adenovirus E1A oncogene on members of the AP-1 transcription factor family

H van Dam  1 , R Offringa, I Meijer, B Stein, A M Smits, P Herrlich, J L Bos, A J van der Eb
Affiliations

Differential effects of the adenovirus E1A oncogene on members of the AP-1 transcription factor family

H van Dam et al. Mol Cell Biol. 1990 Nov.

Abstract

The adenovirus early region 1A (E1A) oncogene interferes with the expression level and activity of the AP-1 transcription factor family. E1A abolished the transactivating function of AP-1 (Jun/Fos), which binds to the 12-O-tetradecanoylphorbol-13-acetate-responsive element of the collagenase gene (collTRE). In contrast, the activity of another member of the AP-1 family that binds to the c-junTRE was not repressed. The mRNA expression of the c-jun gene was, in fact, strongly elevated in various cell types expressing the E1A gene of either adenovirus type 5 (Ad5) or Ad12. The regulation of the junB gene by adenovirus E1A, on the other hand, depended both on the cell type and on the transforming adenovirus serotype. The fact that E1A-induced alterations in the repertoire of AP-1 transcription factors depend on its transforming domain in conserved region 1 suggests that the effects are relevant for the transformation process.

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