Post-transcriptional regulation of the Ras-ERK/MAPK signaling pathway
- PMID: 21688267
- DOI: 10.1002/jcp.22899
Post-transcriptional regulation of the Ras-ERK/MAPK signaling pathway
Abstract
The Ras-ERK/MAP (Mitogen-Activated Protein) kinase signaling pathway governs many cellular processes such as proliferation, differentiation, cell fate, homeostasis, and survival in all eukaryotes. Constitutive activation of the Ras-ERK/MAPK signaling pathway often leads to promotion of abnormal cell growth and tumorigenesis. Although the regulation of the Ras-ERK/MAPK signaling pathway by post-translational modification has been well elucidated, post-transcriptional regulations of this pathway are beginning to emerge in invertebrates and this work is extended to humans. In this review, we describe the conserved regulation of Ras-ERK/MAPK signaling by RNA-binding proteins (PUF, KH-domain, HuR, and LARP) and microRNAs (let-7 family miRNAs) and important implications for human diseases including cancers.
Copyright © 2011 Wiley Periodicals, Inc.
Similar articles
-
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer.Oncogene. 2007 May 14;26(22):3291-310. doi: 10.1038/sj.onc.1210422. Oncogene. 2007. PMID: 17496923 Review.
-
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.Nat Cell Biol. 2003 May;5(5):427-32. doi: 10.1038/ncb978. Nat Cell Biol. 2003. PMID: 12717443
-
Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways.Oncogene. 2000 Sep 28;19(41):4685-94. doi: 10.1038/sj.onc.1203836. Oncogene. 2000. PMID: 11032018
-
Activation and role of MAP kinase-dependent pathways in retinal pigment epithelial cells: ERK and RPE cell proliferation.Invest Ophthalmol Vis Sci. 2002 Sep;43(9):3091-8. Invest Ophthalmol Vis Sci. 2002. PMID: 12202534
-
Coordinating ERK/MAPK signalling through scaffolds and inhibitors.Nat Rev Mol Cell Biol. 2005 Nov;6(11):827-37. doi: 10.1038/nrm1743. Nat Rev Mol Cell Biol. 2005. PMID: 16227978 Review.
Cited by
-
Hyaline cartilage tissue is formed through the co-culture of passaged human chondrocytes and primary bovine chondrocytes.J Histochem Cytochem. 2012 Aug;60(8):576-87. doi: 10.1369/0022155412449018. Epub 2012 May 19. J Histochem Cytochem. 2012. PMID: 22610463 Free PMC article.
-
miRNAs and Leukotrienes in Respiratory Syncytial Virus Infection.Front Pediatr. 2021 Apr 29;9:602195. doi: 10.3389/fped.2021.602195. eCollection 2021. Front Pediatr. 2021. PMID: 33996675 Free PMC article. Review.
-
ERK1/2 can feedback-regulate cellular MEK1/2 levels.Cell Signal. 2015 Oct;27(10):1939-48. doi: 10.1016/j.cellsig.2015.07.003. Epub 2015 Jul 9. Cell Signal. 2015. PMID: 26163823 Free PMC article.
-
Post-transcriptional gene regulation by RNA-binding proteins in vascular endothelial dysfunction.Sci China Life Sci. 2014 Aug;57(8):836-44. doi: 10.1007/s11427-014-4703-5. Epub 2014 Aug 8. Sci China Life Sci. 2014. PMID: 25104457 Free PMC article. Review.
-
Atorvastatin Prevents Glutamate Uptake Reduction Induced by Quinolinic Acid Via MAPKs Signaling.Neurochem Res. 2016 Aug;41(8):2017-28. doi: 10.1007/s11064-016-1913-1. Epub 2016 Apr 15. Neurochem Res. 2016. PMID: 27084771
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
