Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Jul;64(7):3532-6.
doi: 10.1128/JVI.64.7.3532-3536.1990.

Human cytomegalovirus immediate-early two protein region involved in negative regulation of the major immediate-early promoter

T W Hermiston  1 , C L Malone, M F Stinski
Affiliations

Human cytomegalovirus immediate-early two protein region involved in negative regulation of the major immediate-early promoter

T W Hermiston et al. J Virol. 1990 Jul.

Abstract

The immediate-early two (IE2) gene products of human cytomegalovirus negatively regulate gene expression from the major immediate-early promoter in permissive human fibroblasts. A mutational analysis of the IE2 proteins indicated that the carboxyl-terminal region is required for negative regulation. The IE2 proteins that lack amino acid residues 365 to 519, or the carboxyl-terminal amino acids failed to negatively regulate. Most of the amino-terminal portion of the IE2 protein was not required for negative regulation. A possible explanation of the negative effect on downstream expression by the IE2 proteins is discussed.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Virol. 1977 Oct;24(1):261-76 - PubMed
    1. J Virol. 1990 Apr;64(4):1498-506 - PubMed
    1. J Virol. 1978 Jun;26(3):813-6 - PubMed
    1. Virology. 1978 Sep;89(2):643-6 - PubMed
    1. J Virol. 1979 Apr;30(1):414-6 - PubMed

Publication types

LinkOut - more resources