Sensing hot and cold with TRP channels
- PMID: 21591901
- DOI: 10.3109/02656736.2011.554337
Sensing hot and cold with TRP channels
Abstract
The past decade has witnessed the cloning of a new family of ion channels that are responsive to temperature. Six of these transient receptor potential (TRP) channels are proposed to be involved in thermosensation and are located in sensory nerves and skin. The TRPV1, TRPV2, TRPV3, and TRPV4 channels have incompletely overlapping functions over a broad thermal range from warm to hot. Deletion of the individual TRPV1, TRPV3, and TRPV4 channels in mice has established their physiological role in thermosensation. In all cases thermosensation is not completely abolished - suggesting some functional redundancy among the channels. Notably, the TRPV2 channel is responsive to hot temperatures in heterologous systems, but its physiological relevance in vivo has not been established. Cool and cold temperatures are sensed by TRPM8 and TRPA1 family members. Currently, the pharmaceutical industry is developing agonists and antagonists for the various TRP channels. For instance, TRPV1 receptor agonists produce hypothermia, while antagonists induce hyperthermia. Recent investigations have found that different regions of the TRPV1 receptor are responsive to temperature, nociceptive stimuli, and various chemical agents. With this information, it has been possible to develop a TRPV1 compound that blocks responses to capsaicin and acid while leaving temperature sensitivity intact. These channels have important implications for hyperthermia research and may help to identify previously unexplored mechanisms in different tissues that are responsive to thermal stress.
Similar articles
-
Thermal gating of TRP ion channels: food for thought?Sci STKE. 2006 Mar 14;2006(326):pe12. doi: 10.1126/stke.3262006pe12. Sci STKE. 2006. PMID: 16537823 Review.
-
Odontoblast TRP channels and thermo/mechanical transmission.J Dent Res. 2009 Nov;88(11):1014-9. doi: 10.1177/0022034509343413. J Dent Res. 2009. PMID: 19828889
-
[Molecular mechanisms underlying thermosensation in mammals].Brain Nerve. 2009 Jul;61(7):867-73. Brain Nerve. 2009. PMID: 19618865 Review. Japanese.
-
[Molecular mechanisms of thermosensation].Nihon Yakurigaku Zasshi. 2004 Oct;124(4):219-27. doi: 10.1254/fpj.124.219. Nihon Yakurigaku Zasshi. 2004. PMID: 15467255 Review. Japanese.
-
Transient receptor potential channels on sensory nerves.Handb Exp Pharmacol. 2009;(194):261-81. doi: 10.1007/978-3-540-79090-7_8. Handb Exp Pharmacol. 2009. PMID: 19655110 Review.
Cited by
-
CEM43°C thermal dose thresholds: a potential guide for magnetic resonance radiofrequency exposure levels?Eur Radiol. 2013 Aug;23(8):2215-27. doi: 10.1007/s00330-013-2825-y. Epub 2013 Apr 4. Eur Radiol. 2013. PMID: 23553588 Free PMC article.
-
Embryonic thermosensitive TRPA1 determines transgenerational diapause phenotype of the silkworm, Bombyx mori.Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):E1249-55. doi: 10.1073/pnas.1322134111. Epub 2014 Mar 17. Proc Natl Acad Sci U S A. 2014. PMID: 24639527 Free PMC article.
-
Ca2+ as a therapeutic target in cancer.Adv Cancer Res. 2020;148:233-317. doi: 10.1016/bs.acr.2020.05.003. Epub 2020 Jul 9. Adv Cancer Res. 2020. PMID: 32723565 Free PMC article. Review.
-
A Review on the Role of TRP Channels and Their Potential as Drug Targets_An Insight Into the TRP Channel Drug Discovery Methodologies.Front Pharmacol. 2022 May 24;13:914499. doi: 10.3389/fphar.2022.914499. eCollection 2022. Front Pharmacol. 2022. PMID: 35685622 Free PMC article. Review.
-
Thermosensory signaling by TRPM is processed by brain serotonergic neurons to produce planarian thermotaxis.J Neurosci. 2014 Nov 19;34(47):15701-14. doi: 10.1523/JNEUROSCI.5379-13.2014. J Neurosci. 2014. PMID: 25411498 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
