Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Jun 15;27(12):1739-40.
doi: 10.1093/bioinformatics/btr260. Epub 2011 May 5.

Molecular signatures database (MSigDB) 3.0

Arthur Liberzon  1 , Aravind Subramanian, Reid Pinchback, Helga Thorvaldsdóttir, Pablo Tamayo, Jill P Mesirov
Affiliations

Molecular signatures database (MSigDB) 3.0

Arthur Liberzon et al. Bioinformatics. .

Abstract

Motivation: Well-annotated gene sets representing the universe of the biological processes are critical for meaningful and insightful interpretation of large-scale genomic data. The Molecular Signatures Database (MSigDB) is one of the most widely used repositories of such sets.

Results: We report the availability of a new version of the database, MSigDB 3.0, with over 6700 gene sets, a complete revision of the collection of canonical pathways and experimental signatures from publications, enhanced annotations and upgrades to the web site.

Availability and implementation: MSigDB is freely available for non-commercial use at http://www.broadinstitute.org/msigdb.

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
A typical gene set page on the MSigDB web site. The list of genes has been abbreviated from 41 to 2 for the purposes of this figure.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Ashburner M, et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat. Genet. 2000;25:25–29. - PMC - PubMed
    1. Barrett T, et al. NCBI GEO: archive for high-throughput functional genomic data. Nucleic Acids Res. 2009;30:D5–D15. - PMC - PubMed
    1. Cahan P, et al. Meta-analysis of microarray results: challenges, opportunities, and recommendations for standardization. Gene. 2007;401:12–18. - PMC - PubMed
    1. Culhane A, et al. GeneSigDB – a curated database of gene expression signatures. Nucleic Acids Res. 2009;38:D716–D725. - PMC - PubMed
    1. Dietmann S, et al. CCancer: a bird's eye view on gene lists reported in cancer-related studies. Nucleic Acids Res. 2010;38(Suppl):W118–W123. - PMC - PubMed

Publication types