Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein
- PMID: 2154613
- PMCID: PMC249255
- DOI: 10.1128/JVI.64.3.1353-1356.1990
Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein
Abstract
Stable protein complexes between the large T antigens of mouse, monkey, baboon, or human polyomaviruses and the retinoblastoma protein were detected by an in vitro coimmunoprecipitation assay. All of the large T antigens tested were able to bind to both human and mouse retinoblastoma polypeptides, showing that these interactions have been conserved during evolution.
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