Inositol 1,4,5-trisphosphate receptor subtype-specific regulation of calcium oscillations

doi:10.1007/s11064-011-0457-7

Review

. 2011 Jul;36(7):1175-85.

doi: 10.1007/s11064-011-0457-7. Epub 2011 Apr 11.

Inositol 1,4,5-trisphosphate receptor subtype-specific regulation of calcium oscillations

Songbai Zhang¹, Nicolas Fritz, Cristian Ibarra, Per Uhlén

Affiliations

PMID: 21479917
PMCID: PMC3111726
DOI: 10.1007/s11064-011-0457-7

Review

Inositol 1,4,5-trisphosphate receptor subtype-specific regulation of calcium oscillations

Songbai Zhang et al. Neurochem Res. 2011 Jul.

. 2011 Jul;36(7):1175-85.

doi: 10.1007/s11064-011-0457-7. Epub 2011 Apr 11.

Authors

Songbai Zhang¹, Nicolas Fritz, Cristian Ibarra, Per Uhlén

Affiliation

¹ Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden.

PMID: 21479917
PMCID: PMC3111726
DOI: 10.1007/s11064-011-0457-7

Abstract

Oscillatory fluctuations in the cytosolic concentration of free calcium ions (Ca(2+)) are considered a ubiquitous mechanism for controlling multiple cellular processes. Inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)R) are intracellular Ca(2+) release channels that mediate Ca(2+) release from endoplasmic reticulum (ER) Ca(2+) stores. The three IP(3)R subtypes described so far exhibit differential structural, biophysical, and biochemical properties. Subtype specific regulation of IP(3)R by the endogenous modulators IP(3), Ca(2+), protein kinases and associated proteins have been thoroughly examined. In this article we will review the contribution of each IP(3)R subtype in shaping cytosolic Ca(2+) oscillations.

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Figures

**Fig. 1**
Cartoon illustrating the three IP₃R subtypes (IP₃R1, IP₃R2, and IP₃R3) and related protein kinases and interacting proteins involved in the regulation of cytosolic Ca²⁺ oscillations

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References

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1. Berridge MJ. Inositol trisphosphate, calcium signalling. Nature. 1993;361:315–325. - PubMed
1. Foskett JK, White C, Cheung KH, Mak DO. Inositol trisphosphate receptor Ca2+ release channels. Physiol Rev. 2007;87:593–658. - PMC - PubMed
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[1] Mikoshiba K. IP3 receptor/Ca2+ channel: from discovery to new signaling concepts. J Neurochem. 2007;102:1426–1446. - PubMed

[2] Mikoshiba K. IP3 receptor/Ca2+ channel: from discovery to new signaling concepts. J Neurochem. 2007;102:1426–1446. - PubMed

[3] Berridge MJ. Inositol trisphosphate, calcium signalling. Nature. 1993;361:315–325. - PubMed

[4] Berridge MJ. Inositol trisphosphate, calcium signalling. Nature. 1993;361:315–325. - PubMed

[5] Foskett JK, White C, Cheung KH, Mak DO. Inositol trisphosphate receptor Ca2+ release channels. Physiol Rev. 2007;87:593–658. - PMC - PubMed

[6] Foskett JK, White C, Cheung KH, Mak DO. Inositol trisphosphate receptor Ca2+ release channels. Physiol Rev. 2007;87:593–658. - PMC - PubMed

[7] Mikoshiba K, Changeux JP. Morphological, biochemical studies on isolated molecular, granular layers from bovine cerebellum. Brain Res. 1978;142:487–504. - PubMed

[8] Mikoshiba K, Changeux JP. Morphological, biochemical studies on isolated molecular, granular layers from bovine cerebellum. Brain Res. 1978;142:487–504. - PubMed

[9] Mikoshiba K, Huchet M, Changeux JP. Biochemical, immunological studies on the P400 protein, a protein characteristic of the Purkinje cell from mouse, rat cerebellum. Dev Neurosci. 1979;2:254–275. - PubMed

[10] Mikoshiba K, Huchet M, Changeux JP. Biochemical, immunological studies on the P400 protein, a protein characteristic of the Purkinje cell from mouse, rat cerebellum. Dev Neurosci. 1979;2:254–275. - PubMed

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Inositol 1,4,5-trisphosphate receptor subtype-specific regulation of calcium oscillations

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Inositol 1,4,5-trisphosphate receptor subtype-specific regulation of calcium oscillations

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