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. 2011 May 15;203(10):1442-4.
doi: 10.1093/infdis/jir039. Epub 2011 Mar 16.

Norovirus GII-4 causes a more severe gastroenteritis than other noroviruses in young children

Leena Huhti  1 , Evelin D Szakal, Leena Puustinen, Marjo Salminen, Heini Huhtala, Oona Valve, Vesna Blazevic, Timo Vesikari
Affiliations

Norovirus GII-4 causes a more severe gastroenteritis than other noroviruses in young children

Leena Huhti et al. J Infect Dis. .

Abstract

Norovirus (NoV) GII-4 has emerged as the predominant NoV genotype in outbreaks of gastroenteritis worldwide. We determined clinical features of NoV GII-4 associated acute gastroenteritis (AGE) in comparison with AGE associated with other NoV types in infants during seasons 2001 and 2002. During the prospective follow-up period, 128 primary infections of AGE due to NoV were identified in 405 infants; of these, GII-4 was found in 40 cases (31%). NoV GII-4 was associated with longer duration of diarrhea and vomiting than other NoV genotypes, suggesting greater virulence of NoV GII-4.

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