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Review
. 2011:53:155-77.
doi: 10.1016/b978-0-12-385855-9.00007-2.

EGCG, green tea polyphenols and their synthetic analogs and prodrugs for human cancer prevention and treatment

Di Chen  1 , Sheng Biao Wan, Huanjie Yang, Jian Yuan, Tak Hang Chan, Q Ping Dou
Affiliations
Review

EGCG, green tea polyphenols and their synthetic analogs and prodrugs for human cancer prevention and treatment

Di Chen et al. Adv Clin Chem. 2011.

Abstract

Cancer-preventive effects of tea polyphenols, especially epigallocatechin-3-gallate (EGCG), have been demonstrated by epidemiological, preclinical, and clinical studies. Green tea polyphenols such as EGCG have the potential to affect multiple biological pathways, including gene expression, growth factor-mediated pathways, the mitogen-activated protein kinase-dependent pathway, and the ubiquitin/proteasome degradation pathway. Therefore, identification of the molecular targets of EGCG should greatly facilitate a better understanding of the mechanisms underlying its anticancer and cancer-preventive activities. Performing structure-activity relationship (SAR) studies could also greatly enhance the discovery of novel tea polyphenol analogs as potential anticancer and cancer-preventive agents. In this chapter, we review the relevant literature as it relates to the effects of natural and synthetic green tea polyphenols and EGCG analogs on human cancer cells and their potential molecular targets as well as their antitumor effects. We also discuss the implications of green tea polyphenols in cancer prevention.

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Figures

Fig. 1
Fig. 1
Chemical structures of major tea polyphenols and synthetic prodrug of EGCG (EGCG peracetate or Pro-EGCG).
Fig. 2
Fig. 2
Chemical structures of EGCG analogues 4a–8d.
Fig. 3
Fig. 3
Chemical structures of EGCG analogues 9a–13.
See this image and copyright information in PMC

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