[Fcγ receptor and systemic autoimmune disease]
- PMID: 21372507
- DOI: 10.2177/jsci.34.1
[Fcγ receptor and systemic autoimmune disease]
Abstract
The systemic autoimmune disease such as systemic lupus erythematosus (SLE) is characterized by the deposition of immune complexes in multiple organs. Fcγ receptors (FcγR) recognize the Fc portion of IgG and are important in determining the response of leukocytes to deposited immune complexes. FcγR also provide positive and negative regulation of immune cell responses. The activatory FcγR including the FcR common γ chain take balance with Fcγ RIIB, the only inhibitory FcγR. Development of lupus-like autoimmune disease as well as monocytosis in BXSB mice is dependent on the activatory and inhibitory FcγR. In human SLE, dysregulated expression of FcγRIIB on memory B cells is reported and numbers of associations with genetic polymorphism are also reported. The cell-specific modulation of these activatory or inhibitory FcγRs are expected for the new therapeutic strategy in autoimmune diseases.
Similar articles
-
FcgammaRIIB, FcgammaRIIIB, and systemic lupus erythematosus.Ann N Y Acad Sci. 2010 Jan;1183:69-88. doi: 10.1111/j.1749-6632.2009.05132.x. Ann N Y Acad Sci. 2010. PMID: 20146709 Review.
-
Fcgamma receptor-dependent expansion of a hyperactive monocyte subset in lupus-prone mice.Arthritis Rheum. 2009 Aug;60(8):2408-17. doi: 10.1002/art.24787. Arthritis Rheum. 2009. PMID: 19644866
-
Failed up-regulation of the inhibitory IgG Fc receptor Fc gamma RIIB on germinal center B cells in autoimmune-prone mice is not associated with deletion polymorphisms in the promoter region of the Fc gamma RIIB gene.J Immunol. 2005 Aug 1;175(3):1440-9. doi: 10.4049/jimmunol.175.3.1440. J Immunol. 2005. PMID: 16034080
-
Altered expression of Fcgamma and complement receptors on B cells in systemic lupus erythematosus.Ann N Y Acad Sci. 2007 Jun;1108:183-92. doi: 10.1196/annals.1422.020. Ann N Y Acad Sci. 2007. PMID: 17893984 Review.
-
Fcgamma receptors: structure, function and role as genetic risk factors in SLE.Genes Immun. 2009 Jul;10(5):380-9. doi: 10.1038/gene.2009.35. Epub 2009 May 7. Genes Immun. 2009. PMID: 19421223 Free PMC article. Review.
Cited by
-
FcgRIII Deficiency and FcgRIIb Defeciency Promote Renal Injury in Diabetic Mice.Biomed Res Int. 2019 Aug 22;2019:3514574. doi: 10.1155/2019/3514574. eCollection 2019. Biomed Res Int. 2019. PMID: 31534958 Free PMC article.
