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. 2011 Jun;13(3):157-67.
doi: 10.1007/s11912-011-0158-z.

Update: modern approaches to the treatment of localized esophageal cancer

James Welsh  1 , Arya Amini, Anna Likhacheva, Jeremy Erasmus J, Daniel Gomez, Marta Davila, Reza J Mehran, Ritsuko Komaki, Zhongxing Liao, Wayne L Hofstetter, Jeffrey Lee H, Manoop S Bhutani, Jaffer A Ajani
Affiliations

Update: modern approaches to the treatment of localized esophageal cancer

James Welsh et al. Curr Oncol Rep. 2011 Jun.

Abstract

The optimal treatment strategy for esophageal cancer continues to be a topic of debate. Improvements in chemotherapy drugs, surgical techniques, and radiotherapy planning and delivery have led to the design of treatment approaches that are specific to both the stage of the tumor and the overall performance status of the patient. Surgery continues to be the standard treatment option for localized disease, but multimodality treatments that include radiation and chemotherapy with surgery are increasingly used. The next few years will continue to see improvements in radiation techniques, especially proton beam treatment; the development of additional minimally invasive surgical approaches to minimize postoperative side effects; and the discovery of molecular biomarkers to help specifically target treatment of esophageal cancer in individual patients.

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Figures

Fig 1
Fig 1
Dose volume comparison of classic 2D-CRT plan versus SIB-IMRT for dose escalation. (A) Axial, sagittal, and coronal view of a two-dimensional conformal radiotherapy (2D-CRT) plan to deliver 50.4 Gy to a patient with esophageal cancer (similar to the plans used in Intergroup 0123). (B) Simultaneous integrated boost intensity-modulated radiotherapy plan with the gross tumor volume being treated to 64.8 Gy and the planning target volume to 50.4 Gy. (C) Dose–volume histogram of an individual patient comparing a two-dimensional conformal radiotherapy (2D-CRT) plan (dashed line) to 50.4 Gy (similar to that used in Intergroup 0123) to a simultaneous integrated boost (SIB)-intensity-modulated radiotherapy (IMRT) plan (solid line) in which the gross tumor volume is treated to 64.8 Gy and the planning target volume to 50.4 Gy.
Fig 1
Fig 1
Dose volume comparison of classic 2D-CRT plan versus SIB-IMRT for dose escalation. (A) Axial, sagittal, and coronal view of a two-dimensional conformal radiotherapy (2D-CRT) plan to deliver 50.4 Gy to a patient with esophageal cancer (similar to the plans used in Intergroup 0123). (B) Simultaneous integrated boost intensity-modulated radiotherapy plan with the gross tumor volume being treated to 64.8 Gy and the planning target volume to 50.4 Gy. (C) Dose–volume histogram of an individual patient comparing a two-dimensional conformal radiotherapy (2D-CRT) plan (dashed line) to 50.4 Gy (similar to that used in Intergroup 0123) to a simultaneous integrated boost (SIB)-intensity-modulated radiotherapy (IMRT) plan (solid line) in which the gross tumor volume is treated to 64.8 Gy and the planning target volume to 50.4 Gy.
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