A shared mechanism of SoxR activation by redox-cycling compounds
- PMID: 21338412
- DOI: 10.1111/j.1365-2958.2011.07552.x
A shared mechanism of SoxR activation by redox-cycling compounds
Abstract
In this issue of Molecular Microbiology, Gu and Imlay show that a class of compounds known as redox-cycling agents directly activate the transcription factor SoxR of Escherichia coli and cause cellular toxicity independent of the production of the reactive oxygen species superoxide. Despite the fact that redox-cycling agents increase formation of superoxide in E. coli, the results described in this new publication revise the long-held assumption that superoxide is responsible for the activation of SoxR and for all of the major toxic effects of redox-cycling drugs. This study also suggests that the critical function of the SoxRS regulon in E. coli is in protection against redox-cycling agents and not exclusively the defence against superoxide.
© 2011 Blackwell Publishing Ltd.
Comment on
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The SoxRS response of Escherichia coli is directly activated by redox-cycling drugs rather than by superoxide.Mol Microbiol. 2011 Mar;79(5):1136-50. doi: 10.1111/j.1365-2958.2010.07520.x. Epub 2011 Jan 12. Mol Microbiol. 2011. PMID: 21226770 Free PMC article.
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