Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Dec;35(4):647-63.
doi: 10.1007/s12038-010-0072-9.

Epigenetic modulation of host: new insights into immune evasion by viruses

Dwaipayan Adhya  1 , Anirban Basu
Affiliations
Review

Epigenetic modulation of host: new insights into immune evasion by viruses

Dwaipayan Adhya et al. J Biosci. 2010 Dec.

Abstract

Viruses have evolved with their hosts, which include all living species. This has been partly responsible for the development of highly advanced immune systems in the hosts. However, viruses too have evolved ways to regulate and evade the host's immune defence. In addition to mutational mechanisms that viruses employ to mimic the host genome and undergo latency to evade the host's recognition of the pathogen, they have also developed epigenetic mechanisms by which they can render the host's immune responses inactive to their antigens. The epigenetic regulation of gene expression is intrinsically active inside the host and is involved in regulating gene expression and cellular differentiation. Viral immune evasion strategies are an area of major concern in modern biomedical research. Immune evasion strategies may involve interference with the host antigen presentation machinery or host immune gene expression capabilities, and viruses, in these manners, introduce and propagate infection. The aim of this review is to elucidate the various epigenetic changes that viruses are capable of bringing about in their host in order to enhance their own survivability and pathogenesis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Am J Trop Med Hyg. 2000 Jul-Aug;63(1-2):71-5 - PubMed
    1. Curr HIV/AIDS Rep. 2010 Feb;7(1):37-43 - PubMed
    1. Annu Rev Immunol. 2000;18:861-926 - PubMed
    1. Nat Rev Cancer. 2006 Jan;6(1):38-51 - PubMed
    1. Cell. 1988 Jul 15;54(2):275-83 - PubMed

Publication types

MeSH terms

LinkOut - more resources