Atypical chemokine receptors

doi:10.1016/j.yexcr.2011.01.012

Review

. 2011 Mar 10;317(5):556-68.

doi: 10.1016/j.yexcr.2011.01.012. Epub 2011 Jan 25.

Atypical chemokine receptors

Maria Helena Ulvmar¹, Elin Hub, Antal Rot

Affiliations

PMID: 21272574
PMCID: PMC3072526
DOI: 10.1016/j.yexcr.2011.01.012

Review

Atypical chemokine receptors

Maria Helena Ulvmar et al. Exp Cell Res. 2011.

. 2011 Mar 10;317(5):556-68.

doi: 10.1016/j.yexcr.2011.01.012. Epub 2011 Jan 25.

Authors

Maria Helena Ulvmar¹, Elin Hub, Antal Rot

Affiliation

¹ MRC Centre for Immune Regulation, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

PMID: 21272574
PMCID: PMC3072526
DOI: 10.1016/j.yexcr.2011.01.012

Abstract

Atypical chemokine receptors (ACRs) are cell surface receptors with seven transmembrane domains structurally homologous to chemokine G-protein coupled receptors (GPCRs). However, upon ligation by cognate chemokines, ACRs fail to induce classical signaling and downstream cellular responses characteristic for GPCRs. Despite this, by affecting chemokine availability and function, ACRs impact on a multitude of pathophysiological events and have emerged as important molecular players in health and disease. This review discusses individual characteristics of the currently known ACRs, highlights their similarities and differences and attempts to establish their group identity. It summarizes the progress made in mapping ACR expression, understanding their diverse in vitro and in vivo functions of ACRs and uncovering their contributions to disease pathogeneses.

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References

1. Rot A., von Andrian U.H. Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu. Rev. Immunol. 2004;22:891–928. - PubMed
1. Fernandez E.J., Lolis E. Structure, function, and inhibition of chemokines. Annu. Rev. Pharmacol. Toxicol. 2002;42:469–499. - PubMed
1. Colobran R., Pujol-Borrell R., Armengol M.P., Juan M. The chemokine network. II. On how polymorphisms and alternative splicing increase the number of molecular species and configure intricate patterns of disease susceptibility. Clin. Exp. Immunol. 2007;150:1–12. - PMC - PubMed
1. Proost P., Struyf S., Van Damme J. Natural post-translational modifications of chemokines. Biochem. Soc. Trans. 2006;34:997–1001. - PubMed
1. Nibbs R., Graham G., Rot A. Chemokines on the move: control by the chemokine “interceptors” Duffy blood group antigen and D6. Semin. Immunol. 2003;15:287–294. - PubMed

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[1] Rot A., von Andrian U.H. Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu. Rev. Immunol. 2004;22:891–928. - PubMed

[2] Rot A., von Andrian U.H. Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu. Rev. Immunol. 2004;22:891–928. - PubMed

[3] Fernandez E.J., Lolis E. Structure, function, and inhibition of chemokines. Annu. Rev. Pharmacol. Toxicol. 2002;42:469–499. - PubMed

[4] Fernandez E.J., Lolis E. Structure, function, and inhibition of chemokines. Annu. Rev. Pharmacol. Toxicol. 2002;42:469–499. - PubMed

[5] Colobran R., Pujol-Borrell R., Armengol M.P., Juan M. The chemokine network. II. On how polymorphisms and alternative splicing increase the number of molecular species and configure intricate patterns of disease susceptibility. Clin. Exp. Immunol. 2007;150:1–12. - PMC - PubMed

[6] Colobran R., Pujol-Borrell R., Armengol M.P., Juan M. The chemokine network. II. On how polymorphisms and alternative splicing increase the number of molecular species and configure intricate patterns of disease susceptibility. Clin. Exp. Immunol. 2007;150:1–12. - PMC - PubMed

[7] Proost P., Struyf S., Van Damme J. Natural post-translational modifications of chemokines. Biochem. Soc. Trans. 2006;34:997–1001. - PubMed

[8] Proost P., Struyf S., Van Damme J. Natural post-translational modifications of chemokines. Biochem. Soc. Trans. 2006;34:997–1001. - PubMed

[9] Nibbs R., Graham G., Rot A. Chemokines on the move: control by the chemokine “interceptors” Duffy blood group antigen and D6. Semin. Immunol. 2003;15:287–294. - PubMed

[10] Nibbs R., Graham G., Rot A. Chemokines on the move: control by the chemokine “interceptors” Duffy blood group antigen and D6. Semin. Immunol. 2003;15:287–294. - PubMed

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Atypical chemokine receptors

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