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Review
. 2011 May;10(5):649-52.
doi: 10.1039/c0pp00354a. Epub 2011 Jan 21.

Photodynamic therapy enhancement of anti-tumor immunity

Craig M Brackett  1 , Sandra O Gollnick
Affiliations
Review

Photodynamic therapy enhancement of anti-tumor immunity

Craig M Brackett et al. Photochem Photobiol Sci. 2011 May.

Abstract

Photodynamic therapy (PDT) is an FDA-approved modality for the treatment of early-stage disease and palliation of late-stage disease. Pre-clinical studies using mouse models and clinical studies in patients have demonstrated that PDT is capable of influencing the immune system. The effect of PDT on the generation of anti-tumor immunity is regimen-dependent and is tightly linked to the degree and nature of inflammation induced by PDT. However, the precise mechanism underlying PDT-regulated adaptive anti-tumor immunity remains unclear. This review will focus on the current knowledge of immune regulation by PDT.

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