Astrocyte-neuron metabolic relationships: for better and for worse
- PMID: 21236501
- DOI: 10.1016/j.tins.2010.12.001
Astrocyte-neuron metabolic relationships: for better and for worse
Abstract
In recent years, previously unsuspected roles of astrocytes have been revealed, largely owing to the development of new tools enabling their selective study in situ. These exciting findings add to the large body of evidence demonstrating that astrocytes play a central role in brain homeostasis, in particular via the numerous cooperative metabolic processes they establish with neurons, such as the supply of energy metabolites and neurotransmitter recycling functions. Furthermore, impairments in astrocytic function are increasingly being recognized as an important contributor to neuronal dysfunction and, in particular, neurodegenerative processes. In this review, we discuss recent evidence supporting important roles for astrocytes in neuropathological conditions such as neuroinflammation, amyotrophic lateral sclerosis and Alzheimer's disease. We also explore the potential for neuroprotective therapeutics based on the modulation of astrocytic functions.
Copyright © 2010 Elsevier Ltd. All rights reserved.
Similar articles
-
Astrocytic dysfunction: insights on the role in neurodegeneration.Brain Res Bull. 2009 Oct 28;80(4-5):224-32. doi: 10.1016/j.brainresbull.2009.07.012. Epub 2009 Jul 22. Brain Res Bull. 2009. PMID: 19631259 Review.
-
Astrocyte alterations in neurodegenerative pathologies and their modeling in human induced pluripotent stem cell platforms.Cell Mol Life Sci. 2019 Jul;76(14):2739-2760. doi: 10.1007/s00018-019-03111-7. Epub 2019 Apr 23. Cell Mol Life Sci. 2019. PMID: 31016348 Free PMC article. Review.
-
Monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 are involved in both excitotoxin-induced neurodegeneration and regeneration.Exp Cell Res. 2004 Jul 1;297(1):197-211. doi: 10.1016/j.yexcr.2004.02.031. Exp Cell Res. 2004. PMID: 15194436
-
Microglia in amyotrophic lateral sclerosis.Acta Neurol Belg. 2007 Sep;107(3):63-70. Acta Neurol Belg. 2007. PMID: 18072333 Review.
-
Calcium ions in neuronal degeneration.IUBMB Life. 2008 Sep;60(9):575-90. doi: 10.1002/iub.91. IUBMB Life. 2008. PMID: 18478527 Review.
Cited by
-
Reconstruction of genome-scale metabolic models for 126 human tissues using mCADRE.BMC Syst Biol. 2012 Dec 13;6:153. doi: 10.1186/1752-0509-6-153. BMC Syst Biol. 2012. PMID: 23234303 Free PMC article.
-
In vivo neurometabolic profiling in patients with spinocerebellar ataxia types 1, 2, 3, and 7.Mov Disord. 2015 Apr 15;30(5):662-70. doi: 10.1002/mds.26181. Epub 2015 Mar 15. Mov Disord. 2015. PMID: 25773989 Free PMC article.
-
Modeling the heterogeneity of sodium and calcium homeostasis between cortical and hippocampal astrocytes and its impact on bioenergetics.Front Cell Neurosci. 2023 Jan 30;17:1035553. doi: 10.3389/fncel.2023.1035553. eCollection 2023. Front Cell Neurosci. 2023. PMID: 36794264 Free PMC article.
-
Heterogeneity of Astrocytes in Grey and White Matter.Neurochem Res. 2021 Jan;46(1):3-14. doi: 10.1007/s11064-019-02926-x. Epub 2019 Dec 3. Neurochem Res. 2021. PMID: 31797158 Review.
-
Neuronal Hyperexcitability and Free Radical Toxicity in Amyotrophic Lateral Sclerosis: Established and Future Targets.Pharmaceuticals (Basel). 2022 Mar 31;15(4):433. doi: 10.3390/ph15040433. Pharmaceuticals (Basel). 2022. PMID: 35455429 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
