doi: 10.1155/2011/509036.
Epub 2010 Dec 29.
Impact of HPV in Oropharyngeal Cancer
Affiliations
- PMID: 21234307
- PMCID: PMC3018627
- DOI: 10.1155/2011/509036
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Impact of HPV in Oropharyngeal Cancer
J Oncol.
2011.
Abstract
The incidence of oropharyngeal cancers has increased in the western world and Human Papilloma Virus (HPV) has been recognised as a risk factor in the last decades. During the same period the prevalence of HPV in oropharyngeal tumours has increased and HPV has been suggested responsible for the increase. The HPV-positive tumours are today recognized as a distinct subset of head and neck cancers with its own clinopathological and risk profile and have a significantly improved prognosis regardless of treatment strategy. This review summarizes current knowledge regarding human papillomavirus biology, oncogenic mechanisms, risk factors, and impact of treatment.
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