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. 2011 Feb 15;203(4):479-86.
doi: 10.1093/infdis/jiq083. Epub 2011 Jan 7.

Rapid rise in detection of human papillomavirus (HPV) infection soon after incident HIV infection among South African women

Chunhui Wang  1 , Thomas C Wright, Lynette Denny, Louise Kuhn
Affiliations

Rapid rise in detection of human papillomavirus (HPV) infection soon after incident HIV infection among South African women

Chunhui Wang et al. J Infect Dis. .

Abstract

Background: It is well established that the prevalence of human papillomavirus (HPV) infection is increased among human immunodeficiency virus (HIV)-positive individuals, but the temporal relationships between these infections are unclear.

Methods: During a South African cervical cancer screening trial, 5595 women 35-65 years of age were followed up for 36 months; 577 women were HIV positive at enrollment, HIV seroconversion occurred in 123 women, and 4895 women remained HIV negative throughout. Tests for high-risk HPV DNA and cytology were performed on cervical samples, and a colposcopy/biopsy was performed at each visit. The effects of early HIV infection on the risk of HPV infection and HPV-related disease were evaluated.

Results: Among seroconverters, HPV infection prevalence was 20.3% before seroconversion, 23.6% at seroconversion (P = .4), and 49.1% after seroconversion (P = .01). Seroconverters had significantly lower HPV infection prevalence than women with prevalent HIV infection before and at seroconversion (41.8% and 45.9%, respectively) but had similar HPV infection prevalence to women with prevalent HIV infection after seroconversion (49.4%). HIV seroconversion was associated with newly detected HPV infection (adjusted hazard ratio [AHR], 4.02; 95% confidence interval [CI], 2.26-7.13) and increased risk of low-grade cytological abnormalities (AHR, 2.53; 95% CI, 1.16-5.51) compared with HIV-negative women.

Conclusion: Detection of HPV infection increases rapidly within the first years after HIV seroconversion, suggesting that mucosal immune dysfunction occurring at an early stage of HIV infection may influence HPV-related diseases.

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Figures

Figure 1.
Figure 1.
Impact of HIV seroconversion on HPV infection prevalence. This bar chart shows the HPV infection prevalence (with 95% confidence interval [CI]) in participants with incident HIV infection at the visit before, at, and after HIV seroconversion, and in those with prevalent HIV infection and no HIV infection at the equivalent visits. The light gray bars represent the HPV infection prevalence for participants with incident HIV infection; the white bars are for those with prevalent HIV infection; and the dark gray bars are for HIV-negative participants. The error bars represent the 95% CIs.
Figure 2.
Figure 2.
Cumulative Probability of Newly detected HPV infection by study cohort. These Kaplan-Meier curves show the cumulative detection rate of HPV infection among participants who were HPV negative at the time of HIV seroconversion (incident HIV cohort; n = 94) and among those who were HPV negative at 6 months in the prevalent HIV infection group (n = 297) and in the HIV-negative group (n = 3799).
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References

    1. De Vuyst H, Lillo F, Broutet N, Smith JS. HIV, human papillomavirus, and cervical neoplasia and cancer in the era of highly active antiretroviral therapy. Eur J Cancer Prev. 2008;17:545–54. - PubMed
    1. Palefsky J. Human papillomavirus-related disease in people with HIV. Curr Opin HIV AIDS. 2009;4:52–6. - PMC - PubMed
    1. Singh DK, Anastos K, Hoover DR, et al. Human papillomavirus infection cervical cytology in HIV-infected and HIV-uninfected Rwandan women. J Infect Dis. 2009;199:1851–61. - PMC - PubMed
    1. Sun XW, Kuhn L, Ellerbrock TV, Chiasson MA, Bush TJ, Wright TC., Jr. Human papillomavirus infection in women infected with the human immunodeficiency virus. N Engl J Med. 1997;337:1343–9. - PubMed
    1. Palefsky JM, Minkoff H, Kalish LA, et al. Cervicovaginal human papillomavirus infection in human immunodeficiency virus-1 (HIV)-positive high-risk HIV-negative women. J Natl Cancer Inst. 1999;91:226–36. - PubMed

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