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. 2011 Jun;10(2):391-6.
doi: 10.1007/s10689-010-9410-1.

Familial gastric cancer: update for practice management

Giovanni Corso  1 , Daniele Marrelli, Franco Roviello
Affiliations

Familial gastric cancer: update for practice management

Giovanni Corso et al. Fam Cancer. 2011 Jun.

Abstract

About 90% of gastric carcinoma presents a sporadic setting and only 10% shows a familial cluster; among this group, 1-3% are considered as hereditary syndromes, with a clear genetic pathway. The most important genetic mechanisms are associated with CDH1 germline mutations, causing the hereditary diffuse gastric cancer syndrome. Other inherited predispositions with gastric carcinoma are the hereditary nonpolyposis colorectal cancer, Li-Fraumeni and Peutz-Jeghers syndromes. In this brief update, we described these principal hereditary syndromes offering a simple management to physicians where are these diseases diagnosed.

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