The potential of combinations of drug-loaded nanoparticle systems and adult stem cells for glioma therapy
- PMID: 21183214
- DOI: 10.1016/j.biomaterials.2010.11.056
The potential of combinations of drug-loaded nanoparticle systems and adult stem cells for glioma therapy
Abstract
The prognosis of patients with malignant glioma remains extremely poor, despite surgery and improvements in radio- and chemo-therapies. Nanotechnologies hold great promise in glioma therapy as they protect the therapeutic agent and allow its sustained release. However, new paradigms permitting tumor-specific targeting and extensive intratumoral distribution must be developed to efficiently deliver nanoparticles. Modifications and functionalizations of nanoparticles have been developed to specifically track tumor cells. However, these nanoparticles have yielded few clinical results due to intra-patient heterogeneity and inter-patient variability. Stem cells with a specific tropism for brain tumors could be used as delivery vehicles for nanoparticles. Indeed, these cells have a natural tendency to migrate and distribute within the tumor mass and they can also incorporate nanoparticles. Stem cell therapy combined with nanotechnology could be a promising tool to efficiently deliver drugs to brain tumors.
Copyright © 2010 Elsevier Ltd. All rights reserved.
Similar articles
-
Mesenchymal stem cells as cellular vehicles for delivery of nanoparticles to brain tumors.Biomaterials. 2010 Nov;31(32):8393-401. doi: 10.1016/j.biomaterials.2010.07.048. Epub 2010 Aug 5. Biomaterials. 2010. PMID: 20688391
-
Ferrociphenol lipid nanocapsule delivery by mesenchymal stromal cells in brain tumor therapy.Int J Pharm. 2012 Feb 14;423(1):63-8. doi: 10.1016/j.ijpharm.2011.04.058. Epub 2011 Apr 30. Int J Pharm. 2012. PMID: 21554935
-
Angiopep-conjugated poly(ethylene glycol)-co-poly(ε-caprolactone) nanoparticles as dual-targeting drug delivery system for brain glioma.Biomaterials. 2011 Jun;32(18):4293-305. doi: 10.1016/j.biomaterials.2011.02.044. Epub 2011 Mar 21. Biomaterials. 2011. PMID: 21427009
-
Drug-loaded nanoparticle systems and adult stem cells: a potential marriage for the treatment of malignant glioma?Oncotarget. 2013 Mar;4(3):378-96. doi: 10.18632/oncotarget.937. Oncotarget. 2013. PMID: 23594406 Free PMC article. Review.
-
Stem cells as vehicles for the treatment of brain cancer.Neurosurg Clin N Am. 2007 Jan;18(1):71-80, ix. doi: 10.1016/j.nec.2006.10.001. Neurosurg Clin N Am. 2007. PMID: 17244555 Review.
Cited by
-
Targeting and treatment of glioblastomas with human mesenchymal stem cells carrying ferrociphenol lipid nanocapsules.Int J Nanomedicine. 2015 Feb 12;10:1259-71. doi: 10.2147/IJN.S69175. eCollection 2015. Int J Nanomedicine. 2015. PMID: 25709447 Free PMC article.
-
Cell delivery of therapeutic nanoparticles.Prog Mol Biol Transl Sci. 2011;104:563-601. doi: 10.1016/B978-0-12-416020-0.00014-0. Prog Mol Biol Transl Sci. 2011. PMID: 22093229 Free PMC article.
-
Functionalized nanostructures with application in regenerative medicine.Int J Mol Sci. 2012;13(3):3847-3886. doi: 10.3390/ijms13033847. Epub 2012 Mar 22. Int J Mol Sci. 2012. PMID: 22489186 Free PMC article. Review.
-
Advancements in Engineering Planar Model Cell Membranes: Current Techniques, Applications, and Future Perspectives.Nanomaterials (Basel). 2024 Sep 13;14(18):1489. doi: 10.3390/nano14181489. Nanomaterials (Basel). 2024. PMID: 39330645 Free PMC article. Review.
-
Impacts of blood-brain barrier in drug delivery and targeting of brain tumors.Bioimpacts. 2012;2(1):5-22. doi: 10.5681/bi.2012.002. Epub 2012 Feb 2. Bioimpacts. 2012. PMID: 23678437 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
