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. 2011 Jan;39(Database issue):D146-51.
doi: 10.1093/nar/gkq1138. Epub 2010 Nov 25.

lncRNAdb: a reference database for long noncoding RNAs

Paulo P Amaral  1 , Michael B Clark, Dennis K Gascoigne, Marcel E Dinger, John S Mattick
Affiliations

lncRNAdb: a reference database for long noncoding RNAs

Paulo P Amaral et al. Nucleic Acids Res. 2011 Jan.

Abstract

Large numbers of long RNAs with little or no protein-coding potential [long noncoding RNAs (lncRNAs)] are being identified in eukaryotes. In parallel, increasing data describing the expression profiles, molecular features and functions of individual lncRNAs in a variety of systems are accumulating. To enable the systematic compilation and updating of this information, we have developed a database (lncRNAdb) containing a comprehensive list of lncRNAs that have been shown to have, or to be associated with, biological functions in eukaryotes, as well as messenger RNAs that have regulatory roles. Each entry contains referenced information about the RNA, including sequences, structural information, genomic context, expression, subcellular localization, conservation, functional evidence and other relevant information. lncRNAdb can be searched by querying published RNA names and aliases, sequences, species and associated protein-coding genes, as well as terms contained in the annotations, such as the tissues in which the transcripts are expressed and associated diseases. In addition, lncRNAdb is linked to the UCSC Genome Browser for visualization and Noncoding RNA Expression Database (NRED) for expression information from a variety of sources. lncRNAdb provides a platform for the ongoing collation of the literature pertaining to lncRNAs and their association with other genomic elements. lncRNAdb can be accessed at: http://www.lncrnadb.org/.

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Figures

Figure 1.
Figure 1.
Representative screenshots of lncRNAdb showing (A) the search bar and (B) a lncRNA catalogued in lncRNAdb. Figure 1A shows the search fields available for querying the database and some of the pre-made descriptors available. Figure 1B depicts part of the annotation and references for the Neat1 transcript.
See this image and copyright information in PMC

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