Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Dec;11(12):834-48.
doi: 10.1038/nrm3012.

MET signalling: principles and functions in development, organ regeneration and cancer

Livio Trusolino  1 , Andrea Bertotti, Paolo M Comoglio
Affiliations
Free article
Review

MET signalling: principles and functions in development, organ regeneration and cancer

Livio Trusolino et al. Nat Rev Mol Cell Biol. 2010 Dec.
Free article

Abstract

The MET tyrosine kinase receptor (also known as the HGF receptor) promotes tissue remodelling, which underlies developmental morphogenesis, wound repair, organ homeostasis and cancer metastasis, by integrating growth, survival and migration cues in response to environmental stimuli or cell-autonomous perturbations. The versatility of MET-mediated biological responses is sustained by qualitative and quantitative signal modulation. Qualitative mechanisms include the engagement of dedicated signal transducers and the subcellular compartmentalization of MET signalling pathways, whereas quantitative regulation involves MET partnering with adaptor amplifiers or being degraded through the shedding of its extracellular domain or through intracellular ubiquitylation. Controlled activation of MET signalling can be exploited in regenerative medicine, whereas MET inhibition might slow down tumour progression.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Mol Biol Cell. 1998 Aug;9(8):2185-200 - PubMed
    1. Cancer Cell. 2004 Jul;6(1):61-73 - PubMed
    1. Nat Rev Cancer. 2002 Apr;2(4):289-300 - PubMed
    1. Oncogene. 2004 Jul 1;23(30):5131-7 - PubMed
    1. Nat Rev Mol Cell Biol. 2008 Aug;9(8):628-38 - PubMed

Publication types

MeSH terms

Substances