Review
doi: 10.1016/j.bbrc.2010.11.067.
Epub 2010 Nov 19.
Heme oxygenase-1 comes back to endoplasmic reticulum
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- PMID: 21094129
- DOI: 10.1016/j.bbrc.2010.11.067
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Review
Heme oxygenase-1 comes back to endoplasmic reticulum
Biochem Biophys Res Commun.
.
Abstract
Originally identified as a rate-limiting enzyme for heme catabolism, heme oxygenase-1 (HO-1) has expanded its roles in anti-inflammation, anti-apoptosis and anti-proliferation for the last decade. Regulation of protein activity by location is well appreciated. Even though multiple compartmentalization of HO-1 has been documented, the functional implication of this enzyme at these subcellular organelles is only partially elucidated. In this review we discuss the endoplasmic reticulum (ER)-residing HO-1 and its cytoprotective activity against ER stress.
Copyright © 2010 Elsevier Inc. All rights reserved.
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