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Review
. 2010 Nov;9(11):1315-24.
doi: 10.1586/erv.10.118.

Respective roles of TLR, RIG-I and NLRP3 in influenza virus infection and immunity: impact on vaccine design

Takeshi Ichinohe  1
Affiliations
Free article
Review

Respective roles of TLR, RIG-I and NLRP3 in influenza virus infection and immunity: impact on vaccine design

Takeshi Ichinohe. Expert Rev Vaccines. 2010 Nov.
Free article

Abstract

Influenza A virus is the etiological agent of a highly contagious acute respiratory disease that causes epidemics and considerable mortality annually. It has become increasingly evident that influenza viral infection is recognized by at least three classes of pattern-recognition receptors, including TLR-7, the retinoic acid inducible gene-I and nucleotide-binding domain and leucine-rich-repeat-containing protein 3, a member of the Nod-like receptor family. This article highlights the roles of different types of innate immune receptors in influenza virus immunity versus immunopathology.

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